Postoperative Delirium
Conditions
Brief summary
Patients undergoing cardiac surgery were recruited. Baseline characteristics of all subjects were collected. The 3-minute Delirium diagnostic Scale (3D-CAM) was used to screen the POD group and non-POD group from the recruited subjects during the first 7 days after surgery. Peripheral blood samples were collected 1 day before surgery and 2 day after surgery. . Plasma was isolated from peripheral blood for subsequent proteomic analysis.
Detailed description
Patients undergoing noncardiac surgery were recruited. Baseline characteristics of all subjects were collected. The 3-minute Delirium diagnostic Scale (3D-CAM) was used to screen the POD group and non-POD group from the recruited subjects during the first 7 days after surgery. Peripheral blood samples were collected 1 day before surgery and 2 day after surgery. Plasma was isolated from peripheral blood for subsequent proteomic analysis. To study the characteristics of proteins on a large scale, including protein expression levels, post-translational modifications, protein-protein interactions, etc., so as to obtain a comprehensive understanding of disease occurrence, cell metabolism and other processes at the protein level. Assessment of imbalanced protein expression in peripheral blood using protein profiling may allow us to better understand the pathological changes occurring at the molecular level of POD. Early detection of patients at high risk of POD can optimize perioperative management and promote rapid postoperative recovery.
Interventions
None listed
Sponsors
Xuzhou Central Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Age ≥65 years old, regardless of gender. * The patient had clear consciousness and no cognitive impairment, and could cooperate with the investigation and follow-up. * The ASA classification is I-Ⅲ.
Exclusion criteria
* severe neurological or psychiatric disorders. * drug and alcohol abuse. * Patients with cognitive impairment caused by various reasons such as neuropsychiatric symptoms. *
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences of Quantitative Proteomics between POD and non-POD | 1 day before surgery | Plasma was isolated from peripheral blood for subsequent proteomic analysis. Investigators study the characteristics of proteins at a large-scale level. |
| Differences of Quantitative Proteomics between POD and non-POD after surgery | 2 day after surgery | Plasma was isolated from peripheral blood for subsequent proteomic analysis. Investigators study the characteristics of proteins at a large-scale level. |
Contacts
Primary ContactYangzi Zhu, Doctor
Backup ContactLiwei Wang, Doctor
Outcome results
None listed