Lymphatic Insufficiency
Conditions
Brief summary
This study wil examine the effect of altered intrathoracic pressure on lymphatic function, by investigating the lymphatic vessels in the lower limb during mechanical ventilation. The lymphatic function will be examined using Near-Infrared Fluorescence Imaging.
Detailed description
This study wil examine the effect of altered intrathoracic pressure on lymphatic function. This will be done by investigating peripheral lymphatic vessels on patients undergoing surgery for malformations of the jaw who are being mechanically ventilated. Subjects will be examined on two occasions. One to establish baseline function, and one during surgery following a ventilation protocol with altered PIP and PEEP.
Interventions
PROCEDUREElevated pressure ventilation
Elevated pressure ventilation is defined as a raise in PIP and PEEP by 10 cmH2O from each patients original pressure setting, although never higher than a PIP of 30 cmH2O.
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients undergoing surgery for jaw malformations * Age \> 18 years * Informed consent * Cardiopulmonary healthy
Exclusion criteria
* History of Cardiac disease * History of pulmonary disease * History of lymphatic disease * Peripheral edema * Chronic infectious disease * Age \> 30 years * BMI \> 30
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Peripheral lymphatic velocity (centimeters/second) | 3 hours | Peripheral lymphatic fluid velocity (centimeters/second) will be calculated based upon NIRF sequences. |
| Peripheral lymphatic frequency (contractions/minute) | 3 hours | Peripheral lymphatic contraction frequency (contractions/minute) will be calculated based upon NIRF sequences. |
Countries
Denmark
Contacts
Primary ContactLene Thorup, MD
Outcome results
None listed