GI Cancer, Liver Cancer
Conditions
Brief summary
This study aims to collect biospecimens and explore the correlation of genomics and prognosis in alimentary tract cancers.
Detailed description
In this study, the investigators will collect clinical specimens of alimentary tract cancers and perform DNA and RNA analysis to identify genetic alterations for the development of a comprehensive somatic mutation databases and investigate their potential correlation with clinical, radiological and pathological variables. The genomics study included but not limited to target gene panel sequencing, whole exome sequencing, whole genome sequencing, bulk RNA sequencing, single cell RNA sequencing and metagenomics.
Interventions
None listed
Sponsors
National Cheng-Kung University Hospital
National Health Research Institutes, Taiwan
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Inclusion criteria
* Able to sign the informed consent * Age \>= 20 * Histology proved pancreatic cancer, esophageal cancer, gastric cancer, hepatocellular carcinoma, cholangiocarcinoma, colorectal cancer * Agree to provide tumor/normal tissue including but not limited to surgical specimen, biopsy, cytology specimen, bile, urine or stool * Agree to receive blood sampling 20ml at first time and 10ml during each follow-up (total sampling amount no more than 30ml per month)
Exclusion criteria
* Cannot cooperate with blood sampling
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of subjects who still survive at 1 year | 1 year | 1 year overall survival rate |
Countries
Taiwan
Contacts
Primary ContactYung-Yeh Su, MD
Outcome results
None listed