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Wastewater Surveillance to Boost COVID-19 Vaccine Uptake

Utilizing Wastewater Surveillance Data in a Communications Campaign to Boost Vaccination Uptake in New York State: a Comparison-control Trial

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05766189
Enrollment
100000
Registered
2023-03-13
Start date
2023-03-01
Completion date
2025-12-31
Last updated
2026-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vaccination, Wastewater Surveillance

Brief summary

The goal of the study is to determine the effect of a communications campaign sharing wastewater surveillance data to influence vaccine uptake in a metropolitan and non-metropolitan environment. The study will be conducted in Onondaga and Cayuga counties in New York State. Individuals of all ages within the selected counties, located in metropolitan and non-metropolitan environments will receive the intervention. The evaluation study design is a comparison-control trial. The primary outcome measure is the proportion of vaccine-eligible individuals in the county that received the COVID-19 vaccine stratified by type of vaccine dosage and age group. Vaccination data will be aggregated to the county by the State Department of Health and shared with the research team. Wastewater data will be pulled from the wastewater surveillance network. A difference in differences analysis will be used to estimate the effect of the intervention on both the outcomes between intervention and comparison groups following the intervention, while adjusting for potential confounding factors.

Interventions

BEHAVIORALWastewater vaccine prompts

Social media communications showing levels of SARS-CoV-2 in wastewater

Sponsors

Syracuse University
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE

Intervention model description

Difference-in-differences

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* None - county-level vaccine uptake - no direct interaction with people getting vaccines

Exclusion criteria

* None

Design outcomes

Primary

MeasureTime frameDescription
Vaccine uptakeup to 3 monthsNumber of individuals receiving a booster COVID-19 vaccine

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026