Microbial Colonization
Conditions
Brief summary
The oral cavity is an easily accessible anatomical site that accurately reflects the health of the individual. The mouth is considered an early indicator of biological aging, leading to the identification of oral biomarkers predictive of future alterations. Current data show that the oral health of high level athletes is globally altered with an increase in cariogenic indexes, an increased incidence of periodontitis, dental trauma and dry mouth syndromes. Few studies have focused on the oral microbiota compared to mouthguards used in rugby or boxing which seem to induce dysbiosis, a recent study shows an effect of ketogenic diet on bacterial changes in the mouth of endurance athletes. This project focuses on the impact of intensive sport practice on oral health and the identification of oral biomarkers associated with physical activity. The objective of this study is to investigate the impact of the amount of endurance sport practice on oral microbiota and oral health in young adults. the hypothesis is that a sedentary lifestyle and high-level sport induce depletion and/or changes in the oral microbiota compared to regular physical activity.
Interventions
OTHERsalivar and gum sampling
Saliva will then be collected by salivary spit and a mucosal smear will be taken using a swab passed at the junction of the tooth and the gum
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Be between 18 and 30 years old * If practicing sports, it must be an endurance sport as main activity (cycling or running)
Exclusion criteria
* Practice more than 3 hours of swimming per week * Have taken anti-inflammatory drugs, less than 48 hours before the study * Have taken antibiotics and/or probiotics, less than 3 weeks before the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Analysis of the oral microbiota in healthy individuals engaged in endurance physical activity at different levels. | 3 years | Microbiological screening will be performed using an innovative methodology based on microfluidic PCR (BiomarkHD) (number of bacterial colonies) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quantification of salivary inflammatory markers in healthy individuals who perform endurance physical activity at different levels. | 3 years | numer and type of salivary inflammatory markers will performed using multiplex analysis technology developed by the firm Meso Scale Diagnostic (MSD). |
Countries
France
Outcome results
None listed