Intra-arterial Thrombectomy
Conditions
Brief summary
Early rehabilitation is feasible for stroke patients is still under debate. In addition, IA thrombectomy has been a new treatment for the past few years and currently no known research exploring the efficacy of very early rehabilitation after thrombectomy, or any possible rehabilitation-related adverse effects. Therefore, in this study, the investigators will investigate the effectiveness of earlier rehabilitation intervention after IA thrombectomy for cerebral large vessel occlusion based on functional independence.
Detailed description
The study will be the prospective randomized controlled trial, where patients eligible for inclusion will be randomly assigned to earlier rehabilitation group or control group. The investigators will analyze the correlation between frequency/intensity of rehabilitation and primary/secondary outcomes. Dose-response analysis for earlier rehabilitation will be performed.
Interventions
OTHERexercise
exercise group: first bed exercise after 0\ 24hr onset ; sit at bed after 24\ 48hr onset control group: first bed exercise after 24\ 48hr onset ; sit at bed after 48\ 72hr onset
Sponsors
National Taiwan University Hospital Hsin-Chu Branch
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
1. Cerebral stroke due to infarction of large vessels in the anterior circulation, including internal carotid artery (, middle cerebral artery (MCA) M1 or M2 segment, anterior cerebral artery (ACA) A1 segment 2. Receive arterial thrombectomy (IA thrombectomy) 3. Stable vital signs include heartbeat less than 130 bpm, systolic blood pressure less than 180mmHg, blood oxygen SpO2 \>92% 4. No use of pressors, oxygen masks or respirators after arterial thrombectomy
Exclusion criteria
1. Posterior circulation large vessel stroke 2. Functional score (mRS) ≥ 3 points before the stroke 3. Other contraindications for rehabilitation treatment 4. Neurosurgery immediately after this stroke 5. Those who cannot receive rehabilitation within one week of stroke due to serious medical problems 6. After the stroke, two specialists judged the end of life and arranged palliative and palliative treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Modified Rankin Scale (mRS) | 3rd months after stroke | Modified Rankin Scale (mRS) at 3rd months after stroke:6 grades(higher grades means more disability) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Barthel Index | 1st and 3rd months after stroke | sum score:0\ 100(higher score means more functional independence ) |
| Modified Rankin Scale (mRS) | 1st months after stroke | Modified Rankin Scale (mRS) at 3rd months after stroke:6 grades(higher grades means |
| Fugl-Meyer Assessment | 1st and 3rd month after stroke | U/E total score:66 L/E total score:34 the higher score means better movement performance |
Countries
Taiwan
Contacts
Primary ContactHsing-Yu Chen
Backup ContactMeng Ting Lin, MD
Outcome results
None listed