Comparing Different Regional Blocks for Analgesia After Off-pump Cardiac Surgery

Analgesic Effects of Erector Spinae Plane Block Versus Superficial Parasternal Intercostal Plane Block Combined With Rectus Sheath Block After Off Pump Cardiac Surgery: A Randomised Trial

Status

Active, not recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05763810

Enrollment

Registered

2023-03-10

Start date

2023-03-15

Completion date

2025-12-31

Last updated

2025-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgesia

Brief summary

This study aims to compare the analgesic effects of erector spinae plane block versus Superficial Parasternal Intercostal Plane Block block along with rectus sheath block after off-pump cardiac surgery

Detailed description

General anaesthesia will be used for all patients. induction by midazolam 0.05-0.1 mg/kg, fentanyl 2-5 µ/kg, propofol 1-2 mg/kg, and atracurium 0.5 mg/kg for intubation. Maintenance by sevoflurane in oxygen-air mixture. regional blocks will be used after the induction of anaesthesia. Intraoperative analgesia will be maintained by fentanyl infusion 1-2 µ/kg/h while morphine sulphate 2.5-5mg will be used as rescue analgesia when pain score\>4 beside acetaminophen 1000 mg /6 hours

Interventions

OTHERErector Spinae Plane Block

Erector Spinae Plane Block

OTHERSuperficial Parasternal Intercostal Plane Block combined with Rectus Sheath Block

Superficial Parasternal Intercostal Plane Block combined with Rectus Sheath Block

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* American Society of anaesthesiologists physical status classification II-III * Elective off-pump cardiac surgery

Exclusion criteria

* Cognitive impairment * Allergy to local anaesthetics * Renal and/or hepatic dysfunction * Ejection fraction\< 45%

Design outcomes

Primary

Measure	Time frame	Description
Total opioid consumption	Perioperative.	µg and mg

Secondary

Measure	Time frame	Description
Extubation time	Perioperative	minutes
Duration of post anaesthesia care unit stay	Perioperative	minutes
Pain intensity at rest and exercise	Perioperative.	Visual analogue score: a score from 0 to 10(0= no pain and 10 the worst imaginable pain)
Postoperative vomiting	Perioperative	number (%)
Duration of hospital stay	Postoperative up to 4 weeks	days
Postoperative nausea	Perioperative	number (%)

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026