Screening for Lung Cancer in Subjects With Family History of Lung Cancer

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05762731

Enrollment

1520

Registered

2023-03-10

Start date

2023-02-01

Completion date

2028-05-01

Last updated

2026-06-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Cancer

Keywords

Lung cancer, Screening, Family history

Brief summary

Lung cancer can be detected via screening of high-risk individuals, i.e current or ex-heavy smokers, with low-dose computer tomography (LDCT) of thorax. The National Lung Screening Trial in US and the NELSON trial in Europe demonstrated reduction in lung cancer mortality with LDCT screening for lung cancer. In Hong Kong, however, there is a prominence of female never-smokers with lung cancer. There is no identifiable risk factors for non-smokers with lung cancer except family history of lung cancer. The hypothesis is that lung cancer screening for subjects with family history of lung cancer, can detect early lung cancer.

Detailed description

The primary aim of this prospective study is to find out the rate of lung cancer detection in subjects who are first degree relatives of lung cancer patients. Secondary aims include studying the characteristics of screen-detected lung cancer. This is a multi-centered prospective cohort study. 1,520 subjects who are first degree relatives of lung cancer patients at four public hospitals in Hong Kong will be screened. Intervention Detailed questionnaires and LDCT Thorax will be performed. The primary outcome measure is the number of lung cancers detected by this study. The screening-detection rate of lung cancer in first-degree relatives of lung cancer patients will be estimated.

Interventions

DIAGNOSTIC_TESTLow dose CT thorax

A multi-detector row CT scanner with minimum section collimation of ≤1 mm and minimum number of data acquisition channels ≥ 16will be employed.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

50 Years to 75 Years

Inclusion criteria

* Age 50-75, men or women, smokers or non-smokers * Being first degree relatives (Siblings, children, and parents) of lung cancer subjects * Having no known lung cancer before

Exclusion criteria

* Non-Chinese * Mentally incompetent to give informed consent

Design outcomes

Primary

Measure	Time frame	Description
The rate of lung cancer detection in subjects with family history of lung cancer	An average of 2.5 years	The number of screening-detected lung cancer among first degree relatives of lung cancer patients.

Secondary

Measure	Time frame	Description
The characteristics of screening detected lung cancer	An average of 2.5 years	Stage distribution of lung cancer detected.

Countries

Hong Kong

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 10, 2026