Metastatic Esophageal Squamous Cell Carcinoma
Conditions
Brief summary
This study is a single-arm, prospective, phase II trial for patients with metastatic esophageal squamous cell carcinoma (ESCC) who received immunotherapy plus chemotherapy as the first-line treatment. The aim of the study is to determine if intervening with combined local therapy and immunotherapy and chemotherapy in patients with ESCC led to significant improvements in survival and disease control compared with historical data.
Interventions
RADIATIONRadiotherapy
IMRT or SABR for patients with ESCC.
Sponsors
Fudan University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Age 18-80, had an Eastern Cooperative Oncology Group performance status score of 0-1; 2. Patients had unresectable or recurrent esophageal squamous cell carcinoma that precluded esophagectomy or definitive chemoradiation, or distant metastatic disease; 3. Patients had received no previous systemic therapy (patients who had progressed ≥6 months after \[neo\]adjuvant therapy or definitive chemoradiation were eligible); 4. Patients accepted at least one cycle of anti-PD-1 immunotherapy combined chemotherapy as 1st line treatment. 5. All lesions of current diagnosis did not receive local treatment such as radiotherapy, surgery, radiofrequency ablation before enrollment. 6. The measurable lesion was determined by the investigator based on the RECIST 1.1 assessment. A lesion located in a previous radiotherapy area can be considered a target lesion if it is confirmed to progress and is considered to be measurable according to RECIST 1.1. 7. Estimated survival time \>12 weeks. 8. The function of vital organs meets the following requirements: Neutrophil absolute count (ANC) ≥ 1.5 × 10\^9 / L platelets ≥ 100 × 10\^9 / L; Hemoglobin ≥ 9g / dL; serum albumin ≥ 2.8g / dL; Total bilirubin ≤ 1.5 × ULN, ALT, AST and / or AKP ≤ 2.5 × ULN; if there is liver metastasis, ALT and / or AST ≤ 5 × ULN; if there is liver metastasis or bone metastasis AKP ≤ 5 × ULN; serum creatinine ≤ 1.5 × ULN or creatinine clearance \> 60 mL / min; For patients with pulmonary lesions or previous lung irradiation who are known or suspected to have impaired lung function, the forced expiratory volume (FEV1) for 1 second of lung function must be above 1L. 9. Female subjects of childbearing age must have a negative urine or serum pregnancy test within 72 hours prior to randomization. Subjects agreed to adequate contraception during the trial. 10. The patient is voluntarily enrolled and obtained the informed consent form signed by the patient or his legal representative.
Exclusion criteria
1. Patients who are prior exposure to immune-mediated therapy. 2. Patients participated in any investigational drug study within 4 weeks preceding the start of treatment. 3. The toxicity of previous anti-tumor treatment has not recovered to ≤ National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) v5.0 level 1 (except for hair loss) or the level specified by the inclusion/
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| OS from start of 1st line treatment in metastatic ESCC | 2 years | Median OS and OS rate at 12 months and 24 months will be analysed based on Kaplan-Meier method and presented along with its 95% confidence interval. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| PFS from start of 1st line treatment in metastatic ESCC | 18 months | Median PFS and PFS rate at 6 months, 12months and 18 months will be analysed based on Kaplan-Meier method and presented along with its 95% confidence interval. |
| Disease control rate | Evaluation at the end of radiotherapy and after every 2 months of systemic therapy. | the ratio of patients with the best therapeutic evaluation is CR, PR and SD |
Countries
China
Contacts
Primary ContactQi Liu, M.D.
Backup ContactKuaile Zhao, M.D.
Outcome results
None listed