Chronic Periodontitis
Conditions
Keywords
Chronic periodontitis, Melatonin, RANKL (Receptor activator nuclear K ligand), ELISA (Enzyme-Linked Immunosorbent Assay), Gingival crevicular fluid
Brief summary
This study was conducted to assess the benefit of locally delivered melatonin gel as adjunctive to scaling and root planning (SRP) in the treatment of chronic periodontitis.
Detailed description
Forty chronic periodontitis selected patients ,divided into two groups. Group I: included 20 chronic periodontitis patients, treated by conventional periodontal therapy SRP combined with intra- pocket application of Melatonin gel once weekly for 1 month begin application at the second week after initial therapy. Group II: included 20 chronic periodontitis patients, treated by SRP combined with the injection of placebo, weekly for one month. The periodontal parameters were recorded at baseline, 1week, 1and 3 months.Gingival crevicular fluid (GCF) samples were collected and a quantitative measurement of receptor activator nuclear K ligand (RANKL) was carried out by using Enzyme-Linked Immunosorbent Assay (ELISA) at baseline, 1week, 1 and 3 months.
Interventions
DRUGMelatonin2%gel
Intra-pocket application of 2% Melatonin gel
DRUGPLACEBO
placebo intra-pocket application
Sponsors
Al-Azhar University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Intervention model description
Forty chronic periodontitis selected patients ,divided into two groups. Group I: included 20 chronic periodontitis patients, treated by conventional periodontal therapy SRP combined with intra- pocket application of Melatonin gel once weekly for 1 month begin application at the second week after initial therapy. Group II: included 20 chronic periodontitis patients, treated by SRP combined with the injection of placebo, weekly for one month.
Eligibility
Sex/Gender
ALL
Age
19 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
clinical diagnosed with chronic periodontitis , must be able to maintan good oral hygiene
Exclusion criteria
Diabetic mellitus immunsuppressive medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Efficacy of Melatonin gel by determine the change on measurements of clinical parameter in chronic periodontitis. | 2 weeks | positive change in clinical parameter by millimeter |
| EFFICACY of Melatonin Gel by positive change measurements of clinical parameter pocket depth ,attachment loss | 1: 3 months | positive change in clinical parameter by millimeter |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| EFFICACY of Melatonin Gel by positive change on concentration level of Receptor activator nuclear K ligand ( RANKL) in Gingival crevicular fluid (GCF) | 3 months | microbiology analysis by Receptor activator nuclear K ligand(ELISA ) by picogram |
Other
| Measure | Time frame | Description |
|---|---|---|
| pre-opertive measurements of clinical parameter in chronic periodontitis | at beginning of trial | negative result in clinical parameter measurments by millimeter |
Countries
Egypt
Outcome results
None listed