Crohn Disease
Conditions
Keywords
fistula, abscess, pediatrics, medical treatment, surgery, drug
Brief summary
Crohn's disease is a inflammatory bowel disease evolving towards the destruction of the intestinal wall resulting in stenosing or perforating complications (fistulas, abscesses). The treatment of perforating Crohn's disease is not codified.
Detailed description
The old dogmas leading to surgery after failure of medical treatment have recently been overturned, particularly since the advent of anti-TNFs. Biotherapies now have a central place, including for complicated forms. Previous studies have already looked at the usefulness of anti-TNFs in stenosing forms, or concerning ano-perineal lesions, but what about digestive fistulas. Indeed, data are scarce, especially in paediatrics.
Interventions
DRUGInfliximab
Drug
PROCEDUREStomy
Surgery
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Minor patients (aged 3 to 18). * Diagnosed with Crohn's disease. * fistulizing crohn's disease
Exclusion criteria
\- perianal crohn disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| No fistula | 12 month | Complete remission = clinical remission and biological remission and iconographic remission: * clinical remission (asymptomatic at 12 months from inclusion). * biological remission (normalization of biological parameters 12 months after inclusion). * iconographic remission (no active lesion, and in particular no visualized fistula) |
Outcome results
None listed