Construction of an Ultrasound Profile and a Mammographic Profile Corresponding to the Different Molecular Subtypes of Brest Cancer. A Retrospective Study

Construction of an Ultrasound Profile and a Mammography Profile Corresponding to the Different Molecular Subtypes of Brest Cancer. A Retrospective Study of 203 Cases Diagnosed During the National Screening Campaign in 2015-2018 (PROFILS)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05757232

Acronym

PROFILS

Enrollment

203

Registered

2023-03-07

Start date

2015-06-30

Completion date

2018-07-31

Last updated

2023-03-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer

Keywords

screening campaign, molecular profile, tomosynthesis, ultrasound, mammography

Brief summary

PROFILS is a retrospective, exploratory study on data collected in 203 breast cancer cases diagnosed during a national screening campaign from 2015 to 2018. The aim of the study is to analyse histological, clinical and radiological data collected during the screening campaign to build an ultrasound profile and a mammographic profile corresponding to brest cancers' different molecular sub-types (Luminal A, Luminal B, HER2+, Triple negative) using the BI-RADS classification. The study has the following objectives: * To compare molecular profiles of breast cancers detected in a cohort of women diagnosed with tomosynthesis and ultrasound with molecular profiles of brest cancers detected in the cohort of women diagnosed with classical mammography and ultrasound * To describe molecular profiles of cancers detected only with ultrasound,

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Inclusion criteria

* Women diagnosed with a breast cancer * Detection of a breast cancer during the screening campaign organized between june 2015 and july 2018 in the following geographic zones : Cantal, Haute Loire and Puys de Dôme

Exclusion criteria

* Patients who expressed their opposition to the use of their personal data

Design outcomes

Primary

Measure	Time frame	Description
Tumors' characterization using descriptive criteria of the BI-RADS classification	3 years	The primary outcome will be tumors' characterization using descriptive criteria of the BI-RADS classification within the framework of a mammography and an ultrasound, and then the research of a correlation with the molecular profile in 203 patientes diagnosed with a breast cancer

Secondary

Measure	Time frame	Description
Comparison of molecular profiles of breast cancers detected in the cohorte mammography and ultrasound with molecular profiles of breast cancers detected in the cohorte tomosynthesis and ultrasound	3 years	Chi 2 test or Fisher test for molecular profiles in both cohorts
Description of molecular profiles in breast cancers detected only with ultrasound	3 years	Descriptive statistics concerning the selection of cancers

Outcome results