Peripheral Arterial Disease (PAD) in Cancer Patients
Conditions
Keywords
Peripheral arterial disease (PAD), Cancer patients, 22-326
Brief summary
Researchers are studying whether people with risk factors for blood circulation disease have a condition called peripheral arterial disease (PAD). People with PAD have poor blood circulation because of narrowing or blocks in blood vessels caused by fat or calcium deposits (atherosclerosis). The study researchers think that PAD may lead to worse outcomes in cancer treatment, but people with cancer are not routinely tested for the disease. The purpose of this study is to find out how common PAD is among people with cancer who have risk factors for blood circulation disease, and to compare how often PAD is diagnosed in different racial groups
Interventions
DIAGNOSTIC_TESTABI/TBI
ABI/TBI to be performed after surgery while patient is still admitted at the hospital.
OTHERQuestionnaires
PAD symptoms questionnaire to be administered at baseline before surgery. mLEFS (included in PAD symptoms questionnaire) and WIQ to be administered at baseline before surgery. mLEFS and WIQ will be administered 1 month, 3 months, 6 months after surgery and every 6 months after that for a goal of at least 1 year.
Sponsors
Memorial Sloan Kettering Cancer Center
BMS Foundation
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Cancer patients who are ≥ 65 years old * Either diabetes (on medication or insulin) or smoking history (current smoker, smoking within the last 15 years, ≥ 20 pack years) * Patients who are scheduled for major head and neck, thoracic, abdominal, or pelvic surgery requiring at least a 2-day admission * Ambulatory * ≥ 6 month life expectancy as determined based on clinical judgement by the treating physician. If treating clinician does not confirm life-expectancy ≥ 6 months, will calculate Lee Schoenberg Index using ePrognosis.ucsf.edu.
Exclusion criteria
* Hospice patient, patient with a DNR order * Non-ambulatory, wheelchair/bed bound * \< 6 month life expectancy based on the clinical judgement by the treating physician
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| prevalence of PAD in cancer patients at high-risk for PAD going to surgery | 1 year | Completion of ABI/TBI to be able to assess prevalence of PAD |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORYolanda Bryce, MD
Memorial Sloan Kettering Cancer Center
Outcome results
None listed