Cardiac Output Measurement, Cardiopulmonary Exercise Test, Hypertrophic Cardiomyopathy
Conditions
Brief summary
Fatigue and dyspnea that reduce exercise performance are common symptoms in patients with hypertrophic cardiomyopathy. Since the cause of this functional limitation has not yet been described, this study aims to evaluate the cardiopulmonary parameters measured at cardiopulmonary exercise test in combination with those obtained by non-invasive measurement of cardiac output by impedance (Physioflow) and echocardiography. These results will help to better define the mechanisms underlying limitation in these patients, also in relation to the degree of LVOT obstruction. The aim of the present study is to assess the cardiopulmonary response to exercise in patients with hypertrophic cardiomyopathy, based on the degree of LVOT obstruction, by adding non-invasive measurement of cardiac output by Physioflow and echocardiographic parameters to the cardiopulmonary exercise test parameters associated with stroke volume and cardiac output (ie. VO2/WR, O2pulse) Consecutive patients with a previous diagnosis of hypertrophic cardiomyopathy on optimised medical therapy will be enrolled to perform a cardiopulmonary exercise test with simultaneous measurement of cardiac output and an exercise echocardiogram for clinical routine.
Interventions
None listed
Sponsors
Azienda Sanitaria Universitaria Giuliano Isontina [ASUGI], Università di Trieste, Italy
Azienda Ospedaliera Sant'Andrea
Centro Cardiologico Monzino
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* hypertrophic cardiomyopathy diagnosis
Exclusion criteria
* use of long-term oxygen therapy; * presence of comorbidities affecting the ability to perform cardiopulmonary exercise test or interfering with exercise performance; * concomitant at least moderate chronic obstructive pulmonary disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cardiac output measurement | immediately after the evaluation | Evaluate cardiopulmonary exercise test parameters associated with stroke volume and cardiac output (ie. VO2/WR, O2pulse) with the addition of non-invasive measurement of cardiac output using Physioflow. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation with echocardiographic variables | immediately after the evaluation | Correlate functional and metabolic data with echocardiographic variables collected at rest and under stress. |
Countries
Italy
Contacts
Primary ContactPiergiuseppe Agostoni, Prof.
Outcome results
None listed