Parkinson Disease
Conditions
Brief summary
The main objective of the study is to evaluate the efficacy of 10 sessions of transcranial direct current stimulation of the primary motor cortex to reduce levodopa-induced dyskinesia
Interventions
DEVICETranscranial direct current stimulation
Ten sessions of transcranial direct current stimulation over primary motor cortex to treat levodopa-induced dyskinesia
Sponsors
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* patients with diagnosis of idiopathic Parkinson's disease according to Movement Disorder Society (MDS) criteria and levodopa-induced dyskinesia; * age between 30 and 80 years; * ongoing therapy with levodopa; * fulfillment of requirements for the application of transcranial magnetic stimulation (TMS), assessed by completion of the TMS screening questionnaire.
Exclusion criteria
* patients unable to give informed consent; * cognitive impairment (MMSE ≤ 24); * history of epilepsy; * pregnant women.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reduction of dyskinesia | 15 days | Change in the total score of part III of the Unified Dyskinesia Rating Scale (range 0-112, 112 is the worse outcome) in on motor state at the assessment made three days after the end of treatment compared with the assessment made at baseline in the groups of patients treated with tDCS and sham-stimulation, respectively |
Countries
Italy
Contacts
Primary ContactFrancesco Bove, MD
Outcome results
None listed