Intravenous Ibuprofen Postoperative Analgesia After Abdominal Hysterectomy

Efficacy of Intravenous Ibuprofen in Multimodal Pain Management After Open Abdominal Hysterectomy: A Randomised Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05750264

Enrollment

152

Registered

2023-03-01

Start date

2023-03-04

Completion date

2025-12-31

Last updated

2025-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Operative Analgesia

Brief summary

The current research is designed to investigate the analgesic efficacy of intravenous ibuprofen on the postoperative analgesic requirements, pain intensity and other recovery parameters.

Detailed description

The patients will be given general anaesthesia. Anaesthesia will be induced by propofol 1-2 mg/kg, and fentanyl 1-2 µg/kg. Endotracheal intubation will be facilitated by atracurium 0.5 mg/kg. Anaesthesia will be maintained by isoflurane in oxygen - air mixture. Transversus abdominis plane block will be performed at the end of the operation. A postoperative analgesic regimen according to group allocation will be started.

Interventions

DRUGIbuprofen

800 mg of IV ibuprofen

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* American Society of anaesthesiologists physical status I to III. * Open abdominal hysterectomy operations

Exclusion criteria

* History of gastrointestinal bleeding. * History of intracranial haemorrhage. * Pregnancy and lactation. * Taking angiotensin converting enzyme(ACE) inhibitors or anticoagulation drugs. * Asthmatic, hepatic,renal or heart failure. * Abnormal platelet count.

Design outcomes

Primary

Measure	Time frame	Description
Morphine consumption	Postoperative up to 24 hours	mg

Secondary

Measure	Time frame	Description
Anaesthesia recovery time	Perioperative	Minutes
Duration of post anaesthesia care unit stay	First postoperative 24 hours	Minutes
Time of first ambulation	First postoperative 24 hours	Minutes
Duration of hospital stay	Postoperative up to 4 weeks	Days
Pain intensity	Postoperative up to 24 hours	Visual analogue score: a score from 0 to 10( 0= no pain and 10 the worst imaginable pain)
Mean arterial blood pressure	Perioperative	mmHg
Arterial oxygen saturation	Perioperative	Percentage
End tidal carbon dioxide	Perioperative	mmHg
Respiratory rate	Perioperative	Breath/minute
Heart rate	Perioperative	Beats/minute

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026