The Influence of Exercise and Hydration to the Pharmacological Response to Inhaled Terbutalin and Salbutamol in Men

Status

Withdrawn

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05749523

Enrollment

Registered

2023-03-01

Start date

2013-11-30

Completion date

2014-09-30

Last updated

2023-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

exercise, dehydration, Salbutamol, Terbutalin

Brief summary

To investigate the effects of dehydration and exercise for the urine secretion of beta2-agonists.

Detailed description

No studies have examined the influence of factors such as exercise and dehydration on the pharmacokinetic profile of asthmatic drugs (beta2-agonists). Exercise may modify the metabolism and excretion of drugs, and sweat loss during exercise can result in dehydration, both affecting the urine concentration of the drug.

Interventions

BEHAVIORALExercise

Exercise vs non-exercise

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

MALE

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* men * aerobic capacity more than 50ml / min / kg * more than 5h training pr week

Exclusion criteria

* smokers * allergy for the medicine * chronic diseases

Design outcomes

Primary

Measure	Time frame	Description
Urine concentration of salbutamol and terbutalin	7 days	Urine concentration of salbutamol and terbutalin

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026