Intracranial Aneurysm
Conditions
Keywords
Intracranial Aneurysm
Brief summary
The goal of this clinical trial is to compare intracranial aneurysm patients. The main question it aims to answer are: Which heparinization regimen is most beneficial to patients during surgery for intracranial aneurysms. Participants will be randomized to different intraoperative heparinization regimens: (i) 50 U/kg intravenous (IV) at 1-h intervals reduced by half to a minimum of 1000 u/h; (ii) 70 U/kg IV at 1-h intervals reduced by half to a minimum of 1000 u/h. MRI will be performed within 72 h after surgery, and the DWI sequence of MRI will be analyzed. If there is a comparison group: Researchers will compare different intraoperative heparinization protocol groups to see which dose of intraoperative heparin has the best prognosis for use.
Interventions
DRUGHeparin sodium
Intravenous heparin was administered during intracranial aneurysm embolization with a guide catheter and discontinued at the end of the procedure.
Sponsors
The First Affiliated Hospital with Nanjing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. Greater than 18 years old, less than 75 years old 2. Patients with unruptured intracranial aneurysm were confirmed by DSA. 3. Coagulation function should be normal in the enrolled patients.
Exclusion criteria
1. Dissection aneurysm, blister aneurysm, moyamoya disease or arteriovenous malformation. 2. Previous use of antithrombotic drugs (including anticoagulant or antiplatelet aggregation drugs).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Size of the ischemic focus | This will be evaluated within 24 hours after the procedure. | Cranial MRI will be performed on postoperative patients within 24 hours. The presence of high signal on diffusion weighted imaging sequences indicated the occurrence of cerebral infarction. |
Countries
China
Contacts
Primary ContactHua Lu, Doctor
Outcome results
None listed