Aged, Carbohydrates, Post-induction Hypotension
Conditions
Brief summary
The goal of this Randomized controlled trial is to investigate the effect of shortening the duration of preoperative oral carbohydrate drinks on blood pressure after anesthesia induction in elderly patients undergoing joint replacement surgery. The main question it aims to answer is Whether preoperative oral carbohydrate drinks can reduce the incidence of hypotension after anesthesia-induced hypotension in elderly patients undergoing joint replacement surgery.According to the numerical table method, the patients in the experimental group will drink carbohydrate drinks the night before the operation and 3 hours before the operation, and the control group patients will routinely fast
Interventions
DIETARY_SUPPLEMENTCarbohydrate
To ensure the safety of the trial, preoperative gastric ultrasound measurements will be performed on all patients to assess their gastric volume. See above for other details
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Patients undergoing elective unilateral joint replacement (total hip or knee) 2. ASAⅠ-Ⅲ
Exclusion criteria
1. Diagnosed patients at high risk of reflux aspiration (diabetes mellitus, obesity (BMI\>30), gastrointestinal obstruction, elevated intracranial pressure, and esophageal disease) 2. Eating disorders 3. History of gastrointestinal or epigastric surgery 4. Recent use of drugs that affect gastrointestinal motility 5. Heart disease (severe arrhythmias, severe heart valve disease, heart failure, unstable angina on the day of surgery) 6. Severe poorly controlled hypertension (MAP≥135 mmHg) or hypotension (MAP≤55 mmHg) before induction 7. Difficult airway 8. Severe hepatic and renal insufficiency
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of hypotension | 20 minutes after induction of anesthesia | No surgical manipulation is performed within 20 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Antral cross-sectional area | 30 minutes before anesthesia induction |
| Incidence of hypotension | during the whole operation |
| The dosage of vasoactive drugs | 20 minutes after induction of anesthesia |
| Duration of fasting and drinking | 1 day before the operation |
| Fasting blood glucose and insulin resistance index | 3 hours before the operation |
| Incidence of nausea and vomiting | 1 day after the operation |
| Thirst and hunger VAS score | 3 hours before and 1 day after the operation |
Contacts
Primary Contactchaomin wu, doctor
Backup Contactmin yan, prof.
Outcome results
None listed