Portal Hypertension, Magnetic Resonance Imaging
Conditions
Brief summary
This prospective study was conducted in a tertiary university hospital. The investigators researched the correlation between MRE-assessed stiffness of the liver and spleen and the Hepatic venous pressure gradient (HVPG) values. Furthermore, the investigator evaluated whether MRE-assessed stiffness reflected changes in portal hypertension (PH) after administering non-selective beta-blockers (NSBBs).
Interventions
DIAGNOSTIC_TESTMRE
MRE was performed using a 3T system (Magnetom Skyra; Siemens, Erlangen, Germany) equipped with a combination of a 30-channel body and a 32-channel spine matrix coil.
Sponsors
Yonsei University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* diagnosed liver cirrhosis * requiring prophylactic treatment of esophageal varices
Exclusion criteria
* the coexistence of hepatocellular carcinoma * refractory ascites who regularly underwent large-volume paracentesis * the use of selective beta-blocker or carvedilol therapy for at least 4 weeks * undergoing liver transplantation * contraindication with magnetic resonance imaging
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of liver stiffness and spleen stiffness by MRE | Change from baseline stiffness of MRE at 6 months |
| The change of portal pressure (HVPG) prior to and after treatment with NSBB | Change from baseline and at 6 months |
Countries
South Korea
Outcome results
None listed