Mandible Cyst
Conditions
Brief summary
Mandibular cystic defect healing is a complex process. Various methods have been developed to shorten the bone regeneration time and improve its quality. Autogenous grafting is the gold standard for filling cystic defects due to the osteogenesis property provided by the viable cells but is related to donor site morbidity. Allografts and Xenografts are used for the same purpose. However, the increased cost is their main disadvantage. Bone marrow aspirate concentrate is now used to enhance the healing and regeneration process in many areas of the body with no morbidity and low cost.
Interventions
OTHEREnucleation and filling by Bone marrow aspirate
The iliac crest is palpated along its widest part forming the iliac tubercle ( 5-6 cm posterior to the anterior superior iliac spine), then a 5 mm incision is made 3-4 cm posterior to the ASIS directly on the crest. The needle is advanced between the outer and inner plates of the ileum for a 4-6 cm into the cancellous bone and 10 ml of bone marrow is aspirated. Bone marrow aspirate is processed by a dual centrifugation technique.
OTHERConventional enucleation only
patients were treated conventionally by enucleation and plain collagen sponge only.
Sponsors
Hams Hamed Abdelrahman
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Patients suffering from mandibular cystic defect. * Cystic defect width of 4-8 cm that requires removal under general anesthesia.
Exclusion criteria
* Medically compromised patients contradicting operation. * Previously enucleated lesions. * Previous surgery, tumor, infection to the pelvis affecting the anterior iliac crest. * Infected Cysts
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in pain scores | 1st day, 1 week, 4 weeks, 6 weeks | pain was assessed through a 10-point Visual Analogue Scale (VAS) the scores are categorizied as follows: (0-1= None, 2-4= Mild, 5-7= Moderate, 8-10= Severe) |
| Change in bone density | at baseline, 3 months, 6 months | An immediate postoperative CBCT was be obtained, followed by another one taken after 3 and 6 months postoperatively. The Region of Interest (ROI) feature was used to estimate the mean bone density in the immediate and 6 months scans. The mean bone density in the 6 months CBCT-scan was compared with the immediate postoperative and the preoperative scans and the mean difference between the scans was calculated. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change in wound dehiscence | 1st day, 1 week, 4 weeks, 6 weeks | any signs of wound dehiscence were observed |
Countries
Egypt
Outcome results
None listed