Ambulatory Surgery, Elderly Patients
Conditions
Brief summary
The goal of this clinical trial is to compare remimazolam and etomidate in inducing quality of recovery after day surgery for laryngeal mask general anesthesia in elderly patients. The main question it aims to answer is: • The quality of postoperative recovery induced by remimazolam for laryngeal mask general anesthesia in elderly patients undergoing day surgery is not inferior to that induced by etomidate Participants will be given remimazolam to induce anesthesia。 Researchers will compare etomidate to see if the quality of postoperative recovery.
Interventions
DRUGRemimazolam besylate
Using remimazolam for induction of general anesthesia
DRUGetomidate
Using etomidate for induction of general anesthesia
Sponsors
Xijing Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* undergoing day surgery under laryngeal mask anesthesia * American society of anesthesiologists (ASA) grade 1-3 * BMI\<30kg/m2
Exclusion criteria
* have benzodiazepines drugs in the latest month cognitive dysfunction * Cognitive dysfunction and neuropsychiatric disorders * It was estimated as a difficult airway * There was a history of adrenal insufficiency, porphyria, or chronic corticosteroid therapy * There is a contraindication or allergy to benzodiazepines, opioids, etomidate and its components
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The quality of recovery 15 | postoperative day 1 | The main goal of this study was to assess the QoR using the QoR-15 questionnaire, which is a global measure of recovery after surgery that evaluates five dimensions of recovery: physical comfort (5 items), physical independence (2 items), emotional state (4 items), psychological support (2 items), and pain (2 items). Each item is rated on an 11- point scale based on its frequency on the questionnaire (greater score at greater frequency for positive items and less frequency for negative items). The total score ranged from 0 (poorest recovery quality) to 150 (best recovery quality). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The time of loss of consciousness | within 3 minutes after the end of the intravenous anesthetic | The time of disappearance of the eyelash reflex within 3 minutes after the end of the intravenous anesthetic |
| Adverse events | During stay of post anesthesia care unit (up to 30minutes） | Respiratory, cardiovascular and neurological system adverse events |
| the mean blood pressure，the systolic blood pressure ，the diastolic pressure | From 5 minutes before anesthesia induction to the time point surgery start | Vital signs at different time points |
| heart rate | From 5 minutes before anesthesia induction to the time point surgery start | heart rate at different time points |
| pulse oxygen saturation | From 5 minutes before anesthesia induction to the time point surgery start | pulse oxygen saturation at different time points |
Countries
China
Outcome results
None listed