Endocrine Disruptor Chemicals, Thyroid Cancer
Conditions
Brief summary
the relationship between human exposure to EDCS and TC is poorly investigated and still unclear. The aim of this study is to evaluate the possible role of old and new generation endocrine disruptors in thyroid cancer. The primary aim is to evaluate the difference in the average levels of the main endocrine disruptors (PFAS, including: PFOA, PFOS, PFDA, PFUnA, PFHpS and possibly subsequently other categories, such as bisphenols, phthalates, parabens, PCBs, flame retardants) between patients with and without a diagnosis of thyroid cancer through highly sensitive, selective and precise mass spectrometry methods, such as liquid chromatography combined with tandem mass spectrometry (LC-MS / MS). The secondary aim is to evaluate the relationship between the concentrations of endocrine disruptors and some anamnestic variables studied (for example the type of diet, the use of personal care products).
Interventions
DIAGNOSTIC_TESTBlood and urine diagnostic evaluation
Blood and urine samples will be obtained from both case and control groups in order to evaluate EDCs concentrations
Sponsors
Istituto Auxologico Italiano
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients with a diagnosis of thyroid cancer in the last 5 years (arm A) * patients without a diagnosis of thyroid cancer will match patients included in arm A
Exclusion criteria
* subjects under 18 years old * patients unable to sign the informed consent or questionnaires
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Difference in the average levels of the main endocrine disruptors | At recruitment | The main endocrine disruptors evaluated will be PFAS, including: PFOA, PFOS, PFDA, PFUnA, PFHpS and possibly subsequently other categories, such as bisphenols, phthalates, parabens, PCBs, flame retardants |
| Relationship between the concentrations of endocrine disruptors and anamnestic variables | At recruitment | Relationship between the concentrations of endocrine disruptors and some anamnestic variables studied (for example the type of diet, the use of personal care products). |
Countries
Italy
Contacts
Primary ContactLaura Fugazzola, MD
Outcome results
None listed