MODY, Type 2 Diabetes
Conditions
Brief summary
The goal of this study is to investigate to what extent a 12-week training course for people with type 2 diabetes mellitus (T2DM) or MODY can be conducted in a clinical context with clinically relevant improvements in cardiometabolic risk factors and quality of life? The main questions it aims to answer are: 1. To investigate the feasibility of supervised training for people with T2DM or MODY in a clinical context in Greenland. 2. To investigate evidence of the effect of combined aerobic and strength training on cardiometabolic risk factors and mental well-being. 3. To investigate the signs of efficacy and different interactions with the type of disease.
Detailed description
Globally, type 2 diabetes mellitus (T2DM) is a major public health issue. This is also the fact in Greenland, the biggest island in the world. Twice as many Greenlanders as Danes have diabetes, and this is due to both lifestyle and genes. It is estimated that 7% of T2DM patients in Greenland have Maturity Onset Diabetes of the Young (MODY), which is hereditary and rare elsewhere. Exercise improves blood sugar control in T2DM, reduces cardiovascular risk factors such as hypertension and dyslipidemia, contributes to weight loss and improves fitness and well-being. Less is known of how people with MODY responds to exercise. Today, the Greenlandic health care system only offers supervised physical training to people with osteoarthritis in two towns in Greenland, but in the future, they would like to offer supervised physical training to people with other conditions too. Relevance: As mentioned above, this study aims to evaluate the feasibility of a 12-week supervised physical training intervention for people with T2DM or MODY and to investigate signs of efficacy and different interactions with the type of disease.
Interventions
BEHAVIORALPhysical training
A 12 week supervised training intervention with 1 hour physical training two times a week.
Sponsors
University of Southern Denmark
Steno Diabetes Center Greenland
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Type 2 diabetes or MODY * Living in the capital in Greenland, Nuuk
Exclusion criteria
* Severe heart disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Adherence | Baseline to 12 weeks | Adherence is in this study the proportion of completed training sessions (n=0-24 training sessions). The number of completed training sessions was registered by the physiotherapists. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in BMI | Baseline to 12 weeks | BMI is measured using height and weight. |
| Change in fat mass | Baseline to 12 weeks | Fat mass is measured using tanita body composition analyzer. |
| Change in muscle mass | Baseline to 12 weeks | Muscle mass is measured using tanita body composition analyzer. |
| Change in bone mass | Baseline to 12 weeks | Bone mass is measured using tanita body composition analyzer. |
| Change in blood pressure | Baseline to 12 weeks | Blood pressure is measured with a blood pressure monitor. |
| Change in quality of life | Baseline to 12 weeks | Quality of life is estimated using 12-Item Short Form Survey (SF-12). In the short form SF-12, physical (SF12-PCS) and mental (SF12-MCS) component summary scores are calculated as sub-dimensions. The total score of the physical and mental component summary of the scale varies between 0-100. An increase in the score indicates well-being, and a decrease indicates a state of disability. |
| Change in HDL cholesterol | Baseline to 12 weeks | HDL cholesterol is measured with a blood sample. |
| Change in LDL cholesterol | Baseline to 12 weeks | LDL cholesterol is measured with a blood sample. |
| Change in Total cholesterol | Baseline to 12 weeks | Total cholesterol is measured with a blood sample. |
| Change in triglycerides | Baseline to 12 weeks | Triglycerides is measured with a blood sample. |
| Change in HbA1c | Baseline to 12 weeks | HbA1c is measured with a blood sample. |
Countries
Greenland
Outcome results
None listed