Sleep Disorder, Lung Tumor
Conditions
Brief summary
The goal of this observational study is to observe the lung tumor development in lung tumor patients with long-term sleep disorder. The main questions it aims to answer are: * will long-term sleep disorder promote the malignancy of lung tumor * if so, how exactly will the microenvironment of lung tumor change Participants will receive PSQI scale and MRI functional brain imaging before surgery, blood and tumor tissue will be collected during the surgery. Researchers will set non-sleep disorder group as control group to see if lung tumor microenvironment change when long-term sleep disorder exists in lung tumor patiens.
Interventions
None listed
Sponsors
RenJi Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Inclusion criteria
* 18-75 years old * elective sublobectomy for primary lung tumor * ASA grade I-II * Informed consent of the patient or family
Exclusion criteria
* Combination of serious heart, liver, kidney, central nervous system, blood system, immune system diseases or serious mental illness * Combination of other cancers * untreated active lung infection * patients with preoperative neoadjuvant radiotherapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| tumor microenvironment in sleep-disordered lung cancer patients | 3 months after surgery | we use single cell sequencing to analyze microenvironment alterations of tumor tissues in enrolled patients. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| peripheral blood levels of neurotransmitters in sleep-disordered lung cancer patients | 3 months after surgery | peripheral blood levels of epinephrine, noradrenaline, 5-HT in sleep-disordered lung cancer patients |
| Functional brain imaging in sleep-disordered lung cancer patients | 3 months after surgery | Functional brain imaging |
Contacts
Primary ContactWeifeng Yu
Backup ContactYumiao Shi
Outcome results
None listed