Cardiovascular Risk Categories and Attaining LDL-C Targets in Middle Eastern Adults Aged 30-55 Years of Age

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05745272

Acronym

CREATE

Enrollment

1000

Registered

2023-02-27

Start date

2023-12-11

Completion date

2023-12-24

Last updated

2024-01-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerotic Cardiovascular Risk, Low-density-lipoprotein (LDL) Cholesterol

Keywords

Low-density lipoprotein cholesterol (LDL-C), LDL-C targets, ASCVD risk levels, Middle East population

Brief summary

Individuals evaluated for primary and secondary cardiovascular prevention have different levels of cardiovascular risk These levels of risk are the main determinants of the low-density lipoprotein cholesterol (LDL-C) target blood levels that need to be attained.

Detailed description

Individuals evaluated for primary and secondary cardiovascular prevention fall into different levels of cardiovascular risk according to their clinical profile of having atherosclerotic cardiovascular disease (ASCVD), risk factors, and their SCORE. These levels of risk are the main determinants of the low-density lipoprotein cholesterol (LDL-C) target blood levels that need to be attained using LDL-C-lowering agents (LLA). Contemporary studies that evaluated levels of cardiovascular risk and LDL-C goal attainment in the Middle East are scarce. A prior study (CEPHEUS LEVANT) in the Middle East demonstrated that about 1 in 4 high-risk patients reach LDL-C goals. The current study aims at studying cardiovascular risk categories according to the 2019 ESC/EAS and 2018 ACC/AHA Guidelines, and the attainment of LDL-C treatment goals in consecutive individuals aged 18-55 years who are evaluated in tertiary care centers as inpatients or in ambulatory care settings. The above age bracket was chosen because these are the individuals most prone to acute cardiovascular events with a high prevalence of diabetes mellitus and cigarette smoking.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 55 Years

Inclusion criteria

* Age 18-55 y * Individuals can give a history of the presence or absence of ASCVD and its risk factors

Exclusion criteria

* Age below 18 or older than 55 * Refusal of inability to give history on ASCVD and its risk factors

Design outcomes

Primary

Measure	Time frame	Description
Risk level of ASCVD	12 MONTHS	Categorizing the patients' level of ASCVD risk by the clinical background of CVD, DM, other risk factors and 10% year risk

Secondary

Measure	Time frame	Description
LDL-cholesterol blood level	12 months	Calculating the LDL-C blood level in each patient according to the ASCVD risk category, and whether this level was attained by therapy,

Countries

Jordan

Outcome results