Child, Pneumonia, Prognosis
Conditions
Brief summary
In this study, investigators aimed to develop and validate a risk score to predict severe outcomes (e.g., mortality and ICU admission) in children who were admitted to the Children's Hospital of Fudan University between 2017 and 2022 due to community-acquired pneumonia (CAP). The objectives were as follows. 1. Develop a risk prediction model based on demographic, comorbidity, clinical characteristics, laboratory data, and chest radiographic reports to predict severe outcomes among children hospitalized with CAP; 2. Develop a risk scoring system and determine the cut-off point; 3. Externally validate the easy-to-use risk score.
Interventions
OTHERexposures of interest: epidemiological data, clinical characteristics, laboratory data, and chest radiographic reports
epidemiological data (e.g., age, sex, and residential area), clinical characteristics (e.g., fever, cough, and wheeze), laboratory data (e.g., white blood cell, c-reaction protein, and procalcitonin), and chest radiographic reports (e.g., X-ray, CT, and ultrasound)
Sponsors
Children's Hospital of Fudan University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
29 Days to 18 Years
Healthy volunteers
No
Inclusion criteria
1. Aged between 29 days and 18 years old; 2. Admitted to hospital with signs or symptoms of acute infection (eg, fever) and acute respiratory illness (eg, cough), and radiographic evidence of pneumonia.
Exclusion criteria
1. Pneumonia developed 48 hours after admission or intubation; 2. Chronic pneumonia, tuberculosis, tracheobronchial foreign bodies, aspiration pneumonia, parasitic lung disease, and diffuse pulmonary interstitial/parenchyma disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| in-hospital mortality | from admission to discharge, an average of 7 days | in-hospital mortality among children hospitalized with CAP |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| admission to ICU | from admission to discharge, an average of 7 days | admission to a intensive care unit for over 24 hours |
| septic shock | from admission to discharge, an average of 7 days | occurrence of septic shock during admission |
| treatment for severe pneumonia | from admission to discharge, an average of 7 days | vasoactive agents, positive-pressure ventilation or chest drainage, or extracorporeal membrane oxygenation |
Countries
China
Outcome results
None listed