Healthy
Conditions
Keywords
Virtual Mirror therapy, Electroencephalography, Near infrared spectroscopy
Brief summary
The purpose of this study is to investigate the cerebral activation during visual motor simulation in healthy subjects in 3 conditions: observation (OBS), observation and imagination (OBS-IM) and observation and realization (OBS-REAL). The investigators goal is to compare cerebral activation during the three different tasks using EEG and fNIRS.
Detailed description
Mirror therapy is a rehabilitation technique that has been shown to be effective in restoring upper limb motor skills in patients with stroke. However, it comes up against certain constraints of clinical use such as installation difficulties or the obligation of symmetrical bilateral work. These constraints can be limited by the use of so-called 2nd generation virtual mirror therapy technologies. It is therefore likely that these new technologies will improve the feasibility and effectiveness of mirror therapy in rehabilitation. The brain mechanisms involved in virtual mirror therapy are not yet fully understood. EEG (Electroencephalography) and fNIRS (functional Near Infra Red Spectroscopy) are two functional method that allows to study the cerebral cortex changes during different tasks (like fMRI). These techniques therefore makes it possible to study brain activation under more ecological conditions than fMRI and are therefore particularly suitable for exploring rehabilitation techniques. This research aims to study and compare in healthy subjects, using EEG and fNIRS, the brain regions involved in three tasks using a virtual mirror therapy device (IVS4 apparatus ; Dessintey, France) implying lower limb control. The protocol has 3 conditions : observation (OBS), observation and imagination (OBS-IM) and observation and realization (OBS-REAL). The order of the 3 conditions will then be randomized to avoid potential biases linked to the sequence of conditions. The EEG recording will used the 32 channels ENOBIO apparatus. The fNIRS will used the Brite MKII apparatus
Interventions
DEVICEObservation and imagination (OBS-IM)
Subject is seated in a chair facing IVS4. He places his right lower under the screen. The flexion / extension movement of the ankle at a frequency of 0.5 Hz is then recorded. Then for the mirror effect the software reverses the recorded movement, the lower right limb becomes the lower left limb on the screen. The subject observe the movement but also imagine to realized it.
DEVICEObservation (OBS)
Subject is seated in a chair facing IVS4. He places his right lower under the screen. The flexion / extension movement of the ankle at a frequency of 0.5 Hz is then recorded. Then for the mirror effect the software reverses the recorded movement, the lower right limb becomes the lower left limb on the screen. The subject only observe the movement on the screen during the recordings. The subject does not produce any movement.
DEVICEObservation and realization (OBS-REAL)
Subject is seated in a chair facing IVS4. He places his right lower under the screen. The flexion / extension movement of the ankle at a frequency of 0.5 Hz is then recorded. Then for the mirror effect the software reverses the recorded movement, the lower right limb becomes the lower left limb on the screen. The subject observe the movement on the screen and realized it
Sponsors
Centre Hospitalier Régional d'Orléans
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Subjects aged 18 to 75 years * Sufficient command of the French language to understand the instructions * No known neurological medical history * With social security coverage * Right-handed subjects with a laterality test of Edinburgh QL\> 40 (Oldfield 1971)
Exclusion criteria
* Minor subjects * Adults under guardianship * Adults under guardianship * Pregnant or breastfeeding women * Subjects who have objected to participating in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in the EEG spectral alpha and beta-band power (8-12 and 12-30Hz) during movement (Event related Desynchronisation) | Day 0 | Beta desynchronization in dB normalized to a baseline before the movement. |
| Change in the beta band after movement (Beta-Rebound). | Day 0 | Beta Rebound power in dB normalized to a baseline before the movement. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mean change in the concentration of oxyhemoglobin during the task | Day 0 | Changes in the concentration of oxyhemoglobin during the task measured with Fnirs device |
| Mean change in the concentration of deoxyhemoglobin during the task | Day 0 | Changes in the concentration of deoxyhemoglobin during the task measured with Fnirs device |
Countries
France
Outcome results
None listed