Frailty
Conditions
Brief summary
This study is a observational study in China, which aims to explore the predictive effect of preoperative frailty defined by the modified frailty index in predicting postoperative survival and complications in elderly patients. The objectives of the study include: 1\. To demonstrate that the frailty scale can predict short- and long-term survival after surgery in elderly surgical patients; 2 Demonstrated that frailty as defined by this scale is associated with postoperative complications in older patients
Detailed description
Traditionally, frailty has been described as the form of chronological age. Evaluating the patient's risks based solely on age is difficult, several other factors contribute to physiologic aging and determine functional reserve and response to the risk of postoperative complications. To meet the clinical demand for simpler frailty measurement tools, a simplified 5-index modified frailty index (mFI-5) has been proposed and validated in many literatures. However, there is a lack of evidence on the link between preoperative weakness and poor prognosis in elderly patients undergoing non cardiac surgery. Therefore, the purpose of this study is to verify the prognostic value of mFI-5 for short-term and long-term adverse outcomes such as postoperative delirium, anxiety, depression, acute pain, and mortality in elderly non-cardiac surgery patients. Our hypothesis is that frailty may be highly correlated with postoperative mortality and adverse outcomes in elderly patients undergoing non-cardiac surgery, and that mFI-5 may be an effective risk prediction tool for decision-making and surgical planning.
Interventions
OTHERFrailty Index
The mFI-5 scoring system used in the current study was developed by Saxton and Velanovich by comparing the five variables in the original CSHA-FI with NSQIP database
Sponsors
Weidong Mi
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
(1) participants ≥ 65 years of age;
Exclusion criteria
1. lacked any covariate indicator or missing data for any confounder (such as demographic information, intraoperative surgery or anesthesia information); 2. ASA physical status Ⅴ; 3. Anesthesia other than general intravenous anesthesia or intravenous inhalation anesthesia; 4. Surgery time ≤ 60 min.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 12-month all-cause mortality | postoperative 12-month | 12-month postoperative mortality in elderly patients over 65 years of age |
| 6-month all-cause mortality | postoperative 6-month | 6-month postoperative mortality in elderly patients over 65 years of age |
| 1-month all-cause mortality | postoperative 1-month | 1-month postoperative mortality in elderly patients over 65 years of age |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Readmission rates | postoperative 30-day | The rate of second admissions in elderly patients over 65 years old who underwent surgery within 30 days after surgery |
| Admission to ICU | From the moment of living operation room to the moment of discharge from hospital,up to 7 day | Elderly surgical patients over the age of 65 are admitted to the intensive care unit after surgery |
| major complications | From the moment of living operation room to the moment of discharge from hospital,up to 7 day | Postoperative complications include delirium, anxiety, depression, acute pain, stroke, major adverse cardiac events, acute kidney injury, infection, etc |
Countries
China
Outcome results
None listed