Perioperative Medicine
Conditions
Brief summary
ASPIRE is a prospective, multicenter, observational study that will assess the performance of AUB-HAS2 to predict the occurrence of major adverse cardiovascular events 30-days after a non-cardiac surgery and the additional role of high-sensitivity troponin T and NT-ProBNP biomarkers in the accuracy of different event prediction indexes after non-cardiac procedures.
Detailed description
Primary objectives: Primary objective of the validation arm: to analyze the accuracy of the AUB-HAS2 index in predicting the occurrence of myocardial infarction, stroke and death within 30 days after non-cardiac surgeries. Primary objective biomarker arm: to analyze the additional role of high-sensitivity troponin T and NT-ProBNP biomarkers in the accuracy of different event prediction indexes after non-cardiac surgeries. Secondary objectives: To analyze the potentially preventable factors related to adverse outcomes after non-cardiac surgeries in order to offer subsidies for more assertive guidelines regarding the implementation of perioperative protection strategies. Compare the performance of these scores with others that have already been validated (ACP and Lee - see Annex A).
Interventions
None listed
Sponsors
Hospital Samaritano Paulista
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 40 years, in the preoperative period of non-cardiac procedures, with expected hospitalization for at least 24 hours postoperatively.
Exclusion criteria
* Refusal to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| RATE OF MAJOR ADVERSE CARDIOVASCULAR EVENTS | 30 days | COMPOSITE OF DEATH, MYOCARDIAL INFARCTION AND STROKE |
Secondary
| Measure | Time frame |
|---|---|
| RATE OF MYOCARDIAL INJURY | 30 days |
Countries
Brazil
Contacts
Primary ContactPEDRO DE BARROS E SILVA, MD PhD
Outcome results
None listed