Autoimmune Encephalitis
Conditions
Keywords
anti-GABAbr, autoimmune encephalitis, outcome
Brief summary
First described in 2010, GABA-B-receptor antibodies-associated encephalitis is a disease with a severe vital and functional prognosis. Indeed, functional status is mostly altered by encephalitis and it induced consequences while vital status is mostly engaged by cancer very often associated in the course of the disease, mostly small-cell lung cancer (SCLC). While knowledge is growing on clinical features at each stage of the disease, long-term outcome data is still lacking even if known to be pejorative. In this study, we aimed to describe long-term follow up of all patients who were diagnosed a GABAb-receptor antibodies-associated encephalitis in the French Paraneoplastic Neurological Syndrome Reference Center until now.
Interventions
OTHERLong-term outcome
Autonomy, physical examination, behavioural disorders
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* encephalitis tested positive to GABAbr-antibodies after the examination of CSF samples tested for autoimmune encephalitis at the French Paraneoplastic Neurological Syndrome Reference Center from January 2011 to January 2022.
Exclusion criteria
* tested positive to another onconeural antibody.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Modified-Rankin scale (mRS) | At 60 month (after the beginning of the disease) | Modified-Rankin scale (mRS) ranked from 0 (full autonomy) to 6 (death) |
Countries
France
Outcome results
None listed