Serum Free Amino Acid Concentrations in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy (CRRT)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05739604

Enrollment

Registered

2023-02-22

Start date

2020-06-19

Completion date

2022-12-15

Last updated

2023-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amino Acid Catabolism Disorder, Sepsis

Brief summary

Sepsis is a life-threatening condition associated with high morbidity and mortality. The breakdown of proteins mainly from skeletal muscles leads to the release of free amino acids (FAAs). The serum FAA pool has been repeatedly assessed and found to be significantly altered in patients with sepsis/septic shock. Sepsis is well known to be the most common factor contributing to the development of acute kidney injury in critically ill patients. The investigators want to establish the baseline profile of FAAs and their derivatives in patients with sepsis/septic shock undergoing continuous renal replacement therapy due to sepsis-associated acute kidney injury. Secondly, the investigators want to compare the FAA profiles of the survivors and nonsurvivors.

Interventions

DIAGNOSTIC_TESTBlood sample analysis

The concentrations of AAs and related compounds were determined by liquid chromatography/mass spectrometry (LC/MS)

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* over 18 years of age * present AKI * requiring renal replacement therapy * hospitalized at the ICU.

Exclusion criteria

* acute kidney disease requiring renal replacement therapy prior to admission to the ICU * chronic kidney disease requiring renal replacement therapy prior to admission to the ICU * history of past CRRT.

Design outcomes

Primary

Measure	Time frame	Description
Evaluation the baseline profile of FAAs and their derivatives in serum in a group of patients undergoing continuous renal replacement therapy (CRRT) due to sepsis associated acute kidney injury (SA-AKI) in the Intensive care unit (ICU)	Through study completion, an average of 1 year	Daily analysis of concentrations of amino acids (AA) and related compounds with usage of liquid chromatography/mass spectrometry (LC/MS).

Secondary

Measure	Time frame	Description
Comparison the free amino acids (FAA) profile of survivors and nonsurvivors	Through study completion, an average of 1 year	Daily analysis of concentrations of amino acids (AA) and related compounds with usage of liquid chromatography/mass spectrometry (LC/MS).

Countries

Poland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026