Hepatocellular Carcinoma
Conditions
Keywords
Hepatocellular carcinoma, Tumor micronecrosis, BCLC, TNM, Disease staging
Brief summary
Tumor micronecrosis is a pathological feature that reflects malignant biological behavior in hepatocellular carcinoma (HCC). This study aimed to evaluate the prognostic significance of tumor micronecrosis based on the current BCLC and TNM staging systems, and futher improve the performance of the staging models by establishing modified new staging models including tumor micronecrosis.
Interventions
BEHAVIORALtumor micronecrosis
whether HCC patients have tumor micronecrosis or not
Sponsors
Huizhou Municipal Central Hospital
Second Affiliated Hospital of Nanchang University
Meng Chao Hepatobiliary Hospital of Fujian Medical University
Zhejiang University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* primary and histologically confirmed HCCs * patients who underwent curative liver resection
Exclusion criteria
* simultaneous presence of other tumors * patients who had received preoperative antitumor therapies * no available surgical specimens for evaluating micronecrosis status * gross tumor necrosis and Nscore = 3
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall survival | from date after liver resection until death or last follow-up, whichever came first, assessed up to 72 months | the number of months from the date of surgery to the date of the last follow-up visit or time of death. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Disease-free survival | from date after liver resection until recurrence or last follow-up, whichever came first, assessed up to 72 months | the number of months from the date of surgery to the date of first confirmable recurrence or death |
Countries
China
Outcome results
None listed