COVID-19, Frozen Embryo Transfer
Conditions
Brief summary
This is a prospective observational study. In this study, we aim to investigate the effect of a recent past Covid-19 infection on the live birth rate in the frozen embryo transfer cycles
Interventions
OTHERfrozen embryo transfer
transfer one or two embryos in frozen embryo transfer cycles
Sponsors
ShangHai Ji Ai Genetics & IVF Institute
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 42 Years
Healthy volunteers
No
Inclusion criteria
1. Women aged 20-42 years at the time of ovarian stimulation for in vitro fertilization 2. Women have embryos frozen prior to COVID infection.
Exclusion criteria
1. Previous COVID infection before oocyte retrieval 2. Recipient of oocyte donation 3. Undergoing preimplantation genetic testing 4. Presence of hydrosalpinx or endometrial polyp which is not surgically treated
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| live birth rate | a live birth after 22 weeks gestation | live birth rate of the frozen embryo transfer cycle (\>22 weeks of gestation) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| clinical pregnancy | presence of intrauterine gestational sac on ultrasound at 6 weeks of pregnancy | presence of intrauterine gestational sac on ultrasound |
| ongoing pregnancy | viable pregnancy beyond gestation 12 weeks | viable pregnancy beyond gestation 12 weeks |
| biochemical pregnancy | positive blood pregnancy test not followed by clinical pregnancy during 12 weeks gestation | positive blood pregnancy test not followed by clinical pregnancy |
| implantation rate | number of gestational sacs per embryo transferred during 4 weeks of pregnancy | number of gestational sacs per embryo transferred |
| serum hCG level | a blood pregnancy test is performed 14 days after the embryo transfer | serum hCG level |
| ectopic pregnancy | ectopic pregnancy during 12 weeks gestation | pregnancy outside the uterine cavity |
| miscarriage | the loss of a pregnancy before 22 weeks gestation | the loss of a pregnancy before 22 weeks gestation |
| birth weight | a live birth after 22 weeks gestation | birth weight of the baby delivered |
| serum COVID-19 antibody level | 7 days before embryo transfer | serum COVID-19 antibody level immunoglobulin G and immunoglobulin M |
| multiple pregnancy | multiple pregnancy beyond gestation 12 weeks | more than one intrauterine sacs on scanning |
Countries
China
Outcome results
None listed