Sedation and Postoperative Cognitive Functions

The Effect of Sedation on Postoperative Cognitive Functions in Patients Operated for Hip Fracture Under Spinal Anesthesia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05737459

Enrollment

Registered

2023-02-21

Start date

2022-05-01

Completion date

2022-12-31

Last updated

2023-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive Impairment, Femoral Fractures

Keywords

Cognitive Impairment, Mini mental status test, Hip fractures, Ketamine, dexmedetomidine

Brief summary

Patients over the age of 65 who underwent elective surgery for a hip fracture and were sedated during spinal anesthesia were included in the study. Patients who were given ketamine and dexmedetomidine for sedation were included in the study. The Mini Mental Status Tests of the patients measured on the first and third days of the operation in the preoperative period were determined from the hospital records and recorded.

Detailed description

Patients over the age of 65 who underwent elective surgery for a hip fracture and were sedated during spinal anesthesia were included in the study. The cognitive functions of these patients, which were evaluated by a Mini-Mental Test in the preoperative period, on the first and third days of surgery, were recorded from routine patient follow-up forms. Sedation scores of the patients evaluated by Intraoperative Alertness/Sedation Scale (OAA/S) Observer Evaluation were recorded. Intraoperative hemodynamic data were recorded. The interventions applied to the patient were performed by anesthesiologists who were not involved in the study according to their preferences as part of the routine. The researchers were not involved in any intervention performed on the patient, only the data were recorded.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients over the age of 65 who underwent surgery under spinal anesthesia due to hip fracture * Volunteered to participate in the study

Exclusion criteria

* Patients who are under the age of 65 * Patients with known histories of dementia * Patients with Alzheimer's disease * Patients with central nervous system disease * Patients who scored 15 or less according to the Mini Mental Status Test (MMSE) * Patients who underwent surgery under general anesthesia * Patients who refused to voluntarily participate in the study

Design outcomes

Primary

Measure	Time frame	Description
Mini-Mental Status Test	6 months	Evaluation of the effect of sedation with ketamine and dexmedetomidine on postoperative cognitive functions by Mini-Mental Status Test

Secondary

Measure	Time frame	Description
noninvasive mean arterial pressure	6 months	The effect of sedation on perioperative hemodynamics.
The heart rate	6 months	The effect of sedation on perioperative hemodynamics.

Countries

Turkey (Türkiye)

Outcome results