Prostate Cancer
Conditions
Keywords
prostate cancer, functional magnetic resonance imaging(fMRI), Brain function
Brief summary
To explore whether the patients with prostate cancer have functional changes in specific brain areas and changes in psychological and mental characteristics compared with the patients without prostate cancer.
Detailed description
This study was intended to observe the functional changes of brain fMRI in patients with and without prostate cancer enrolled in the cohort of patients who planned to undergo prostate biopsy, in an attempt to discover specific brain region changes in patients with prostate cancer, and lay a foundation for further clarifying the relationship and mechanism between brain region function changes and prostate cancer.
Interventions
DIAGNOSTIC_TESTfunctional magnetic resonance imaging examination、Zung Self Rating Anxiety Scale and Beck Depression Inventory-II
fMRI examination 、Zung Self Rating Anxiety Scale and Beck Depression Inventory-II were performed in these patients within 1 week before biopsy .
Sponsors
Shanghai East Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
1. Between the ages of 18 and 80 2. Patients with prostate biopsy; 3. No history of other malignant tumors; 4. Exclude other malignant tumors; 5. Fully understand the clinical trial protocol and sign informed consent;
Exclusion criteria
1. magnetic resonance contraindications; 2. symptomatic acute or chronic inflammation of the prostate; 3. Patients with brain trauma or brain disease; 4. Patients who have died of other malignancies in the past or are currently suffering from other malignancies; 5. Patients judged by the investigator to be unfit to participate in the clinical trial;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The evaluation of Magnetic Resonance(MR) | Within 1 week before biopsy | To compare the differences in rs-fMRI measures (Amplitude of low frequency fluctuations , Regional Homogeneity and Functional Connectivity ) between prostate cancer group and Non-prostate cancer group. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of anxiety status | Within 1 week before biopsy | Zung Self Rating Anxiety Scale was used to assess anxiety status.By comparing the final score, less than or equal to 10 is considered healthy, and more than 10 is considered abnormal. |
| Assessment of depressive status | Within 1 week before biopsy | Beck Depression Inventory-II was used to assess depressive status.By comparing the final scores, a score of 50 or less is considered healthy and a score of 50 or more is considered abnormal. |
Countries
China
Contacts
Primary ContactShuaidong Wang
Backup ContactHaifeng Wang
Outcome results
None listed