Smoking, Cigarette
Conditions
Brief summary
establishment of a method for extraction and quantification of gingival tissue nicotine in relation to conventional tobacco biomarkers: a pilot study
Detailed description
The study aim to establish a method for extraction and quantification of gingival tissue nicotine. Additionnaly, the relationship between the nicotine tissue intoxication with others smoking indicators will be evaluated as mentionned in the following PICO question: * P: Smoker patients * I: Biopsie of gingival tissue * C: Non-smoker patient * O: nicotine dependence test (FTND), salivary cotinine, fibroblast nicotine, number of cigarette consumed per day (NCC) and the pack-year (PY)
Interventions
DIAGNOSTIC_TESTbiopsie
gingival biopsie
Sponsors
University of Liege
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
Yes
Inclusion criteria
* non smokers * smokers
Exclusion criteria
* not able to have biopsie
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| nicotine | baseline | nicotine in gingival fibroblast |
| nicotine dependance | baseline | Fagerström test for nicotine dependence |
Secondary
| Measure | Time frame |
|---|---|
| salivary cotinine | baseline |
| number of cigarette consumed | baseline |
| pack-year | baseline |
Countries
Belgium
Contacts
Primary ContactLeila Salhi, PhD
Outcome results
None listed