Acute, Ischemic Stroke
Conditions
Keywords
Stroke, Electroacupunture, Cholesterol
Brief summary
The study will make an association between the diagnosis of traditional Chinese medicine that establishes that the syndrome of blood stagnation generates alteration in blood flow, vascular dysfunction, and damage to the endothelium. This process is like what occurs in a stroke. It will use electroacupuncture to change this chronic inflammatory process, and to know the effects and efficacy of this technique in the regulation and modulation of to treat extensive inflammatory diseases. However, this inflammatory response must be associated with serum cholesterol levels, since they are associated with a stroke between the LDL-C/HDL-C ratio and the prognosis after a stroke.
Detailed description
An adequate early standardized diagnosis of ischemic stroke uses different treatment protocols for these patients, depending on their complexity. Therapeutic windows have been associated with better outcomes when reperfusion or recanalization occurs. Someone has shown strongly related clinical outcome in ischemic stroke to the timely revascularization benefit of acupuncture in stroke patients; electroacupuncture intervention on metabolism is associated with effects on the anti-inflammatory mechanism and metabolic modulation, effects of electroacupuncture stimulation at different spinal segmental levels in a rat model of diabetes mellitus, and another vascular effect of electroacupuncture generate the modulation of the elasticity of the blood vessels. Electroacupuncture (EA) stimulation is commonly applied in the treatment of ischemic stroke in the clinic. The efficacy of EA is associated with the acupuncture points, intensity, intervals, and duration of the intervention of the treatment for stroke. The inflammatory response might be associated with serum cholesterol levels since they are associated with a stroke between the LDL-c/HDL-c ratio and the prognosis after a stroke. This study evaluates the impact of electroacupuncture as a modifier of total cholesterol, HDL-c, and LDL-c blood levels and its anti-inflammatory effect in patients with cerebrovascular accidents. Measurement of the post-electroacupuncture serum level (total cholesterol, HDL-c, LDL-c, and triglycerides) will provide adequate information on the influence that these risk factors have on blood vessels and vascular endothelium.
Interventions
DEVICEelectroacupuncture
This is the group that receives real electroacupuncture, applied to selected acupuncture points both on the arms and legs, and on the scalp. All procedures were carried out with disposable needles measuring 0.25 mm in diameter (32-gauge) and 44 mm in length.
Sponsors
China Medical University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
The patients and outcomes assessors were blind to group allocation
Intervention model description
This study is clinical trial randomized in electroacupuncture: use a control group and treatment group design (included sham acupuncture) Practice mainly based on medical experience and evidence from clinical cases of CMUH. clinical measurements are made; blood tests to evidence treatment results.
Eligibility
Sex/Gender
ALL
Age
35 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Diagnosis of acute ischemic stroke from (ICD10 diagnostic code I63 - I66) First-time ischemic stroke diagnosis: confirmed with scanner (TC) and magnetic resonance (MRI) Stable hemodynamic indices according to safety standards in patients with ischemic stroke. The age is between 35 and 80 years old.
Exclusion criteria
Hemorrhagic stroke (diagnostic I61 to diagnostic code I61.9) Cancer patients Recent event trauma requiring hospitalization Patients undergoing immunosuppressive therapy. Drug dependence and abuse. Pregnancy or fertility treatment Required pacemakers.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neurological examination( clinical signs of stroke) | This assessment can be used before and after the electroacupuncture treatment period (1 week, 2 weeks, 4 weeks) stroke patient's ability and independence to care for themselves | National Institutes of Health Stroke Scale (NIHSS) score of 0\~40. Barthel Index (BI) score of:0\~100.The National Visual Analog Scale (VAS) score of: 0\~10. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood sample: comparable laboratory results: | First blood sample take at the time of admission, second blood sample taken, completed electroacupuncture treatment 2 weeks, and control 4 weeks | Total cholesterol,triglycerides,HDL cholesterol,LDL cholesterol.For routine analyses, the extraction time of blood is between 7 and 9:30 a.m. without previous food They are used for the initial measurement of cholesterol levels in the blood and to monitor and compare these levels once the treatment of EA, Sham and the control group has finished (check blood cholesterol levels). |
Countries
Taiwan
Outcome results
None listed