COPD, Healthy
Conditions
Keywords
BFR, COPD, Exercise
Brief summary
The purpose of the study is to investigate the effect of different blood flow restriction (BFR) interventions on muscle function and adaptations both in healthy well-trained individuals and individuals diagnosed with COPD.
Interventions
OTHERBFR during training
Healthy participants and participants diagnosed with COPD will be randomized to either the BFR-ST and BFR-HIT or to HL-ST and HIT
OTHERBFR during rest
Participants experiencing acute exacerbation of their COPD requiring hospitalization will be randomized to either BFR-P, BFR-NMES or the control group throughout their hospitalization.
Sponsors
Morten Hostrup, PhD
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
for participants with COPD group are: * Diagnosis with COPD
Exclusion criteria
participants in the COPD group are * Having experienced an acute exacerbation of COPD within the last 6 weeks (Study A) * Taking part in pulmonary rehabilitation within the last 3 months (Study A) * Presenting with a history of thromboembolic event in the lower limbs. Inclusion criteria for healthy participants are: * Age between 18 and 40 years. * Maximal oxygen uptake (VO2max) of \>55 ml O2/kg/min for men and \>50 ml O2/kg/min for women * BMI of \<26 and normal ECG and blood pressure.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle strength | Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B) | Maximal voluntary isometric contraction of m. quadriceps femoris |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Maximal oxygen consumption | Change assessed from before to after the 6 week intervention | VO2max during incremental exercise |
| Skeletal muscle mitochondrial respiration | Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B) | High resolution respirometry |
| Fiber cross-sectional area | Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B) | Immunohistochemistry to determine fiber cross-sectional area |
| Lean mass | Change assessed from before to after the 6 week intervention | Lean mass assessed by dual X-ray absorptiometry (DXA) |
| Functional exercise capacity | Change assessed from before to after the 6 week intervention (only in individuals with COPD) | Number of repetitions achieved during a 1-minute sit-to-stand test |
| Satellite cells | Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B) | Immunohistochemistry to determine number of satellite cells |
| Myonuclei | Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B) | Immunohistochemistry to determine number of myonuclei |
Countries
Denmark
Contacts
Primary ContactMorten Hostrup
Outcome results
None listed