Microvesicle Particles, Ultraviolet B Radiation
Conditions
Brief summary
This study is designed to assess if ultraviolet B radiation (UVB) found in sunlight causes the release of microvesicle particles in human skin, and if antioxidant vitamins can block their production.
Interventions
DIETARY_SUPPLEMENTVitamin C
Two Vitamin C tablets daily for 8 days.
DIETARY_SUPPLEMENTVitamin E
One Vitamin E tablet daily for 8 days.
Sponsors
Wright State University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
21 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Male subjects * Ages 21 to 45 * Skin type: Fitzpatrick Type I or II
Exclusion criteria
* Have underlying diseases that could affect wound healing * On medications that are known photosensitizers (e.g., doxycycline) or anti-inflammatories (e.g., NSAIDS \[except for low-dose aspirin\] or steroids) * History of abnormal scarring (e.g., keloids) * Should not be on Vitamin C or E supplements for past month * Unable to understand/complete informed consent * Large volar arm tattoos that would inhibit the ability to conduct/evaluate the skin testing * Renal compromise/kidney stones or allergy to Vitamin C/Vitamin E or lidocaine anaesthetic * Use of tanning bends or recent UVB exposure to the areas in the past 3 months * Recent (within 1 week) use to sunscreen to volar forearms
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in microvesicle particles (MVP) levels from baseline | Day 8 | Levels of microvesicle particles will be determined from skin biopsies |
Countries
United States
Outcome results
None listed