Cardiovascular Diseases, Risk Reduction Behavior
Conditions
Keywords
Intermediate to high risk non-cardiac surgery
Brief summary
The goal of this observational study is to learn whether the healthy lifestyle choices made around surgery can influence an individual's long term risk of developing cardiovascular disease. Patients will be observed 1-month prior to and 3-months following surgery to assess their risk of developing cardiovascular disease.
Detailed description
Patients who experience a medical event are often motivated to improve their health by engaging in healthy lifestyle behaviors, such as improving their diet and beginning to exercise. For example, patients who are considered smokers prior to surgery may sometimes stop smoking following surgery. However, we are unsure of other changes following surgery. For example, we are unsure if surgery can initiate any changes in exercise and diet, and we are unsure if these changes can influence the risk of developing cardiovascular disease. Consistent and positive lifestyle changes will likely reduce an individual's risk of developing cardiovascular disease in the long term.
Interventions
BEHAVIORALHealthy lifestyle behaviors around the time of surgery
Healthy lifestyle choices, such as improving diet and beginning to exercise around the time of surgery and it's influence on an individual's long term risk of developing cardiovascular disease.
Sponsors
University Health Network, Toronto
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
45 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Age 45 - 75 years * Scheduled for intermediate- to high risk non-cardiac surgery (intra-thoracic or intra-abdominal surgery, all vascular surgery, intra-cranial neurosurgery, spine surgery) * Expected post-operative length of stay of at least two days, according to the surgeon's expectation * At least two of the following CVD risk factors: History of: Hypertension, Diabetes, Coronary artery disease, Chronic heart failure, Chronic kidney disease, Cerebrovascular disease, Peripheral vascular disease. Obesity (BMI \>25 kg/m2), Current smoking, Poor exercise capacity (\<4 METS)
Exclusion criteria
* Currently participating in a CVD risk reduction program * Patient is scheduled to undergo transplant or has undergone emergency surgery * Life expectancy \<1 year (palliative surgery) * Recent (\<6 months) myocardial infarction or stroke * Surgery scheduled \<1 month * Inability to effectively communicate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Baseline assessment for calculating the pre-operative 10-year CVD event risk | 1 month before surgery | For the baseline assessment, the expected 10-year CVD event risk of each participant will be calculated according to the appropriate CVD event risk prediction score using blood tests, questionnaire to estimate an individual's functional capacity, blood pressure, heart rate and ECG. |
| Follow-up assessment for calculating the post-operative 10-year CVD event risk | 3 months after surgery | For the follow-up assessment, the expected 10-year CVD event risk of each participant will be calculated according to the appropriate CVD event risk prediction score using blood tests, questionnaire to estimate an individual's functional capacity, blood pressure, heart rate and ECG. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Occurrence of Cardiovascular or Non-Cardiovascular event | 30 days after surgery | Cardiovascular related (e.g. Myocardial infarction/injury, mortality, heart failure) or non-cardiovascular related (e.g. surgical site infections, unexpected critical care unit admissions, re-operations). |
Countries
Canada
Contacts
Primary ContactWilton van Klei, MD
Backup ContactMarc Sicova
Outcome results
None listed