Leukoplakia, Oral, Oral Lichen Planus, Potentially Malignant Lesions
Conditions
Keywords
lncRNA DQ786243, saliva, oral potentially malignant lesions, miRNA146a
Brief summary
The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.
Interventions
DIAGNOSTIC_TESTReal-time Polymerase Chain Reaction technique
Real-time Polymerase Chain Reaction technique
Sponsors
Fayoum University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* participants will be divided into 3 groups: Group I: patients suffering from oral lichen planus Group II: patients suffering from leukoplakia Group III: healthy subjects who are systemically free, non-smokers, and not suffering from any oral mucosal lesions.
Exclusion criteria
* Subjects taking any drugs inducing any changes that could affect the salivary flow. * Pregnant females. * Subjects have any allergies, infectious diseases or active dental abscesses during one month before saliva sampling. * Patients receiving any drugs related to the oral lesions in the past 6 month prior to sample collection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| salivary expression of lncDQ786243 in OLP, Leukoplakia, control | 2 months |
Secondary
| Measure | Time frame |
|---|---|
| salivary expression of miRNA146a in OLP, Leukoplakia, control | 2 months |
Countries
Egypt
Outcome results
None listed