Histological Assessment of BMAC Utilized in Sinus Lift

Histological Assessment of Deproteinized Bovine Bone Loaded by Bone Marrow Aspirate Versus Deproteinized Bovine Bone Alone for Guided Sinus Floor Elevation. (A Randomized Controlled Clinical Trial)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05730400

Enrollment

Registered

2023-02-15

Start date

2022-10-30

Completion date

2023-09-15

Last updated

2024-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Implant Site Reaction

Keywords

Bone marrow, Sinus augmentation, Sinus lift

Brief summary

Aim : The aim of present study was to evaluate BMAC/bovine graft utilization in Sinus membrane augmentation on bone quality and quantity. Methodology: sixteen patients suffering from atrophic posterior maxilla with sinus pneumatization were randomly divided into two equal groups: study group: the sinus membrane was elevated with BMAC/bovine graft whereas the control group recieved bovine graft only for sinus floor augmentation. All patients will be evaluated at 1 week, 4 months to measure bone height and bone core biopsy for histological assessment at 4 months during implant placement.

Detailed description

Aim : The aim of present study was to evaluate BMAC/bovine graft utilization in Sinus membrane augmentation on bone height gain and quality of bone on histological assessment. Methodology: sixteen patients suffering from atrophic posterior maxilla with sinus pneumatization were randomly divided into two equal groups: study group: the sinus membrane was elevated with bone marrow aspirate concentrate loaded on bovine graft whereas the control group recieved bovine graft only for sinus floor augmentation. All patients will be evaluated at 1 week, 4 months by CBCT to measure bone height and bone core biopsy for histological assessment at 4 months during implant placement.

Interventions

DRUGBMAC loaded on bovine graft

Bone marrow aspirate concentrate loaded on bovine graft for sinus floor augmentation

DRUGBovine graft only

Bovine graft only for sinus floor augmentation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients with missing upper posterior teeth and atrophic posterior maxilla with a residual bone height ranging from 4 to 6 mm * Patients who has as deficient as 4 mm vertical bone height in posterior maxilla that need bone augmentation before delayed implant placement. * Highly motivated patients

Exclusion criteria

* Patients suffering from any systemic disease or those under any medication that may interfere with normal bone healing. * Patients suffering from any sinus pathosis. * Patients with conditions that could potentially compromise BM quality, previous BMA, or acute illness. * Heavy smoker (\> 20 cigarettes daily)

Design outcomes

Primary

Measure	Time frame	Description
Histological assessment	After 4 months of surgery	Histological assessment of core biopsy obtained at time of implant placement for percentage of new bone formation and residual graft

Secondary

Measure	Time frame	Description
Implant stability	After 4 months of surgery	implant stability immediately following installation after 4 months using ostell device (ISQ scale)
Bone gain	Preoperative, immediate and 4 months Postoperative	Vertical bone height gain from sinus floor on cone beam ct

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026