Cancer Therapy-related Cardiovascular Toxicity
Conditions
Brief summary
The purpose of this study was to explore the relationship between early myocardial injury caused by tumor drug therapy and intestinal microbial structure changes by echocardiographic two-dimensional speckle tracking technique and intestinal microflora structure detection.
Detailed description
This is a monocentric prospective cohort study in which 50 patients treated for malignant tumors will be included. All participants will be followed for 6 months after the initiation of oncology drug therapy. Echocardiography and 2D speckle tracking will be performed and stool and blood samples will be tested before treatment initiation and at 3 and 6 months after initiation.
Interventions
DRUGAntitumor drugs
Anthracyclines, immune checkpoint inhibitors, monoclonal antibodies, and tyrosine kinase inhibitors
Sponsors
Peking University Third Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* With malignant tumors * Will receive antitumor drugs * Could receive regular follow-up for 6 months * Written informed consent
Exclusion criteria
* Satisfactory echocardiographic images could not be obtained * Cardiomyopathy * Coronary artery disease * Heart failure * Arrhythmia requiring intervention * Moderate or severe valvular disease * Acute myocarditis * Refractory hypertension * Participating in other studies of drug intervention
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| At least a 10% decrease in the global longitudinal strain | 6 months | The primary endpoint is at least a 10% decrease in the global longitudinal strain, determined using cardiac 2D STE and compared with baseline. |
Countries
China
Contacts
Primary ContactZhenyu Tian, Doctor
Outcome results
None listed