Colorectal Neoplasms, Perforation Colon, Perforation of Rectum
Conditions
Keywords
endoscopic submucosal dissection, laterally spreading tumors, perforation
Brief summary
Endoscopic resection of superficial colorectal neoplasms decrease risk of colorectal cancer. En bloc resection is necessary for large superficial lesions with risk of superficial submucosal cancer and is advised if feasible for all lesions. Endoscopic submucosal dissection (ESD) allows en bloc resection of large superficial colorectal neoplasms, increasing curative resection rate and decreasing local recurrence risk. However, the risk of perprocedural or delayed perforation is higher compared to wild field piece meal endoscopic mucosal resection. Endoscoping clipping and closing methods mostly allow conservative treatment, but some case still necessitate surgery. The aim of our study is to describe and ananalyse outcomes after perprocedural or delayed perforation in all patients undergoing ESD and analyse the need for surgical intervention.
Interventions
PROCEDUREEndoscopic submucosal dissection
standard ESD performed and complicated with a perprocedural or delayed perforation
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients from the FECCO (NCT04592003) cohort experiencing perprocedural or delayed perforation * age over 18 years old
Exclusion criteria
* patients refusing exploitations of health datas * patient treated with endoscopic mucosal resection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Surgery | 30 days | Rate of surgery following perforation after ESD |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hospital readmission | 30 days | — |
| Curative resection rate | 60 days | — |
| Hospital stay | 60 days | length of hospital stay (days) |
| Risk factors for endoscopic closure failure | 30 days | — |
| 30-days mortality rate | 30 days | — |
| Endoscopically closed perforation rate | 30 days | — |
Countries
Belgium, France
Outcome results
None listed