Chest Ultrasound, Echocardiography, High Frequency Ventilation, Lung Recruitment, Ventilator Lung
Conditions
Keywords
Premature infants
Brief summary
The primary aim of this work is to evaluate the role of high frequency oscillatory ventilation (HFOV) in recruitment of lung in preterm newborns 32 to 37 weeks gestational age with moderate to severe respiratory distress. The secondary aim is to evaluate the role of chest ultrasound in monitoring of lung recruitment in comparison to routine chest x ray in those babies. Also cardiac hemodynamics will be assesed using functional echocardiography.
Interventions
OTHERLung recruitment
establishment of lung recruitment using high frequency ventilation and assessment with chest ultrasound and echocardiography
Sponsors
Alexandria University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Hours to 3 Days
Healthy volunteers
No
Inclusion criteria
* Infants will be enrolled if they are 32 to 37 weeks of gestational age, have respiratory distress (RD) in the first 24 h of life, intubated and have invasive respiratory support using HFOV. Signs of RD are tachypnea (respiratory rate \> 60/min), grunting, nasal flaring, chest retraction, and need of oxygen supplementation or other respiratory support.
Exclusion criteria
1. Known major congenital anomalies including congenital heart diseases. 2. Fetal hydrops. 3. Babies with congenital heart diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| chest US | first 3 days after birth | A mobile device (PHILIPS ® HD11 XE) with a 10-MHz linear probe will be used for chest ultrasound the 12 lung zones will be assessed regarding 1. presence Of A lines, B-lines or C-profile 2. presence or absence of pleural sliding |
| Superior Vena Cava flow in ml/kg/min | first 3 days of life | Superior Vena Cava (SVC) Blood Flow using functional echocardiography |
| estimated pulmonary artery pressure in mmHg | first 3 days of life | Pulmonary artery pressure (PAP) will be assessed by measuring tricuspid valve regurgitation peak velocity: this will be measured in apical 4 chamber view, with continous wave Doppler using modified Bernoulli equation. Systolic pulmonary artery pressure is equivalent to right ventricular systolic pressure in absence of outflow obstruction. Systolic Pulmonary Artery Pressure (SPAP) = Right Ventricular Systolic Pressure = 4x TR2 + Right Atrial Pressure (RAP), with RAP= 3-5 mmHg. |
Countries
Egypt
Contacts
Primary ContactMarwa M Farag, PhD
Backup ContactMohamed Hany Saad, MBBCh
Outcome results
None listed