Tobacco Use Disorder
Conditions
Keywords
Addiction, Nicotine, Smoking Cessation, Relapse, Cognitive remediation, Exercise training
Brief summary
The goal of this subproject is to examine the hypothesized improvement of treatment with chess-based training and sleep enhancement, both together and on their own, in smokers. Participants will undergo fMRI measurements, sleep monitoring. They will then be assigned to one of the four experimental groups, including high-intensity interval training with or without chess-based training.
Detailed description
This subproject aims to improve treatment outcome in patients with tobacco use disorder (TUD) by enhancing cognitive control. Evidence from the first funding period (1st FP) indicates that enhancing cognitive control using cognitive remediation training (CRT, in our case chess-based) can improve outcomes of a standard smoking cessation program. The current project will harness three means to build on this success of enhancing cognitive control by: 1. using our tried-and-tested chess-based training, 2. improving sleep using high-intensity interval training (HIIT), 3. increasing sleep-dependent consolidation of the chess-based training (see Figure 1). We hypothesize that chess-based training and sleep enhance treatment outcome, both together and on their own. To test our hypotheses, we will combine smoking cessation treatment with the aforementioned approaches as app-based add-ons (chess-based training and HIIT). This will not only allow us to apply the training in a cost-efficient way out-side the lab, it may also increase patients' compliance.
Interventions
BEHAVIORALStandard smoking cessation program (SCP)
Each subject will receive a standard SCP as group treatment once a week (1h) over six weeks. This group therapy is based on behavioural therapy and a psycho-educational approach (for more details see Batra & Buchkremer, 2004), and will be carried out by a qualified therapist.
BEHAVIORALCognitive remediation treatment (CRT)
The cognitive remediation treatment (CRT) employs a chess-based battery of tasks (delivered through an app-based online tool), two times per week over six weeks (60min duration per session).
BEHAVIORALHigh-intensity interval training (HIIT evening)
The high-intensity interval training will be delivered through an app environment with several choices of exercise, two times per week over six weeks. The training will include a 5-minutes warm-up and cool down phase. In between, participants will perform four 4-minutes blocks of exercise at high intensity, interspersed with three 3-minute blocks of low intensity (total of 35 minutes exercise).
Sponsors
Central Institute of Mental Health, Mannheim
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* severe tobacco use disorder (TUD) according to DSM-5 * sufficient ability to communicate with investigators and answer questions in both written and verbal format * ability to provide fully informed consent and to use self-rating scales * right-handedness * HIIT can be performed without the risk of side effect (medical sports check)
Exclusion criteria
* severe internal, neurological, and/or psychiatric comorbidities; other Axis I mental disorders other than TUD according to ICD-10 and DSM 5 (except for mild depression, i.e. F32.0, adjustment disorder and specific phobias) in the last 12 months * history of brain injury * severe physical diseases * common
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time until first severe relapse | timepoint 3: follow-up 3 months after end of SCP | days until the first severe smoking relapse after treatment |
| Percentage of abstinent days | timepoint 3: follow-up 3 months after end of SCP | Percentage of abstinent days in the 3 months after treatment |
| Change in smoking urges | 2 time points: before and after 6 weeks SCP | questionnaire of smoking urges (QSU, Müller et al. 2001) |
| Change in neural measures of response inhibition | 2 time points: before and after 6 weeks SCP | SST fMRI task (Gan et al., 2014) |
| Change in neural measures of working memory | 2 time points: before and after 6 weeks SCP | Nback fMRI task (Charlet et al., 2014) |
| Change in neural functional connectivity in the salience network | 2 time points: before and after 6 weeks SCP | resting state connectivity to seed region right anterior insula |
Countries
Germany
Contacts
Primary ContactSabine Vollstädt-Klein, Prof. Dr.
Backup ContactGordon Feld, Dr.
Outcome results
None listed