Retinal Diseases
Conditions
Brief summary
The MRI perfusion imaging using arterial spin labeling (ASL)'s non-invasive technique (i.e. without injection of contrast medium) allows, thanks to recent technological improvement of the spatial resolution, measuring several perfusion parameter of the retinal tissue such as the regional Blood Flow (rBF) or the cerebral blood flow (cBF) expressed in ml/100g/min. Reliable application of ASL thus requires the precision and specificity of the MRI protocol to be tested.
Interventions
DIAGNOSTIC_TESTMRI perfusion imaging using ASL's non-invasive technique
Patients will undergo through an MRI-scan using the ASL MRI sequence, as described per protocol.
Sponsors
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Carrier of target pathologies: TAO optic neuropathy, inflammatory optic neuropathy, ischemic optic neuropathy. * no cardiovascular risk factors or other ophthalmological pathology * adhere to the study protocol after reading the patient information document * signe the informed consent form to participate in the study * do not have any contraindications to an MRI examination
Exclusion criteria
* Usual contraindications to MRI (Pacemaker, Metallic foreign body, Cochlear implant,…) * Severe claustrophobia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Repeatability measurement on volunteers | 2 month | implementing a protocol based on 2 imaging sessions : 1st session with 2 ASL sequences and a 2nd session scheduled 5-7 days later in similar conditions including 1 ASL in volunteers will be applied. This protocol allows assessing the intra-day and the inter-day variability of the measurements using Intra-Class Correlation Coefficient and metric derived from Bland-Altman plots. A total of 20 MRI examinations are planned for this phase of the study. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mesurement of the retinal perfusion by MRI ASL in patient in acute phase | 4 years | Analysing the retinal perfusion by ASL to be able to figure out if the decreased visual acuity has an ischemic etiology. |
| Mesurement of the retinal perfusion by MRI ASLin patient in a chronic phase | 4 years | Following up the disease process (stability, progression or reversal of the decrease in visual acuity). |
Countries
Belgium
Contacts
Primary ContactIdil Günes-Tatar, MD
Backup ContactThierry Duprez, MD
Outcome results
None listed