Rhinitis, Allergic
Conditions
Keywords
nasal polyps, chronic rhinosinusitis, atopic NPs, non-atopic NPs, EGR2
Brief summary
EGR2 may be a target for the treatment of nasal polyps.
Detailed description
There is much debate about the etiology of nasal polyps, so the pathogenesis of nasal polyps still needs to be clarified. Surgery for noninflammatory nasal polyps may be better control, but surgery is not effective for recurrent sinusitis and nasal polyps. Therefore, more research is needed to determine the best targeted therapy for nasal polyps. We found that EGR2 expression was upregulated in CRSwNP patients with allergic rhinitis.In addition, the expression of EGR2 in CRSwNP mucosa was significantly higher than that in the control group, and the expression of EGR2 in CRSwNP with allergic rhinitis was higher than that in CRSwNP without allergic rhinitis. EGR2 may be involved in the pathogenesis of nasal polyps, and may also be related to the severity and recurrence of nasal polyps. EGR2 may be a target for the treatment of nasal polyps.
Interventions
GENETICEGR2
We investigated the expression of EGR2 in patients with nasal polyps through immunohistochemistry.
Sponsors
Zu-xia Ma
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
16 Years to 76 Years
Healthy volunteers
No
Inclusion criteria
All patients were stopped by systemic or topical corticosteroid treatment at least one month before the study.
Exclusion criteria
Patients had NPs accompanied by choanal polyps, fungal nasal sinusitis, cystic fibrosis, acute upper airway upper infection or other systemic diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| expression of EGR2 | one months | expression of EGR2 were analyzed by immunohistochemistry and Western Blot |
Countries
China
Outcome results
None listed