Carcinoma, Pancreatic Ductal
Conditions
Brief summary
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with relatively poor survival. Surgery is the first choice for the treatment of patients with early pancreatic cancer. However, the surgical approach and the extent of resection for patients with pancreatic cancer are controversial at present. The investigators optimized the procedure of standard pancreaticoduodenectomy to selective extended dissection (SED), which is based on the extra-pancreatic nerve plexus (PLX) potentially invaded by tumor. The investigators retrospectively analyzed the clinicopathological data of patients with pancreatic adenocarcinoma who underwent radical surgery in our center from 2011 to 2020. Patients who underwent standard dissection (SD) were matched 2:1 to those who underwent SED using propensity score matching (PSM). The log-rank test and cox regression model were used to analyze survival data. In addition, statistical analyses were performed for the perioperative complications, postoperative pathology and recurrence pattern.
Interventions
PROCEDURESelective extended dissection of pancreaticoduodenectomy
An optimized procedure of pancreaticoduodenectomy which is based on the extra-pancreatic nerve plexus (PLX) potentially invaded by tumor.
Sponsors
Tianjin Medical University Cancer Institute and Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
\- 1) Patients diagnosed as resectable pancreatic cancer were pathologically diagnosed as PDAC after surgery. 2\) Patients received radical surgery (R0) and had complete photos or videos of the operation.
Exclusion criteria
\- 1) The operation records as well as related photo or video data could not reflect the surgical approach and the extent of resection. 2\) Patients with incomplete clinical, pathological, imaging and follow-up information.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease-free survival (DFS) | From the day the patient received surgery to the time the patient was diagnosed with postoperative recurrence, assessed up to 36 months. |
Countries
China
Outcome results
None listed